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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLR1A
All Species:
19.7
Human Site:
Y278
Identified Species:
36.11
UniProt:
O95602
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95602
NP_056240.2
1720
194811
Y278
N
E
G
F
F
L
N
Y
L
F
S
G
M
D
D
Chimpanzee
Pan troglodytes
XP_001135380
1723
195055
Y278
N
E
G
F
F
L
N
Y
L
F
S
G
M
D
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532976
1699
192037
Y260
N
E
G
F
F
L
N
Y
L
F
S
G
L
E
D
Cat
Felis silvestris
Mouse
Mus musculus
O35134
1717
194092
Y285
N
E
G
F
F
L
N
Y
L
F
S
G
L
D
D
Rat
Rattus norvegicus
O54889
1716
194174
Y285
N
E
G
F
F
L
N
Y
L
F
S
G
L
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZL98
1390
155685
Y97
L
P
C
F
H
V
G
Y
F
K
A
V
I
G
I
Frog
Xenopus laevis
NP_001082182
1730
195193
Q283
K
N
E
G
F
F
L
Q
H
L
F
S
G
I
T
Zebra Danio
Brachydanio rerio
XP_001922839
1693
190636
H270
T
E
G
F
F
L
K
H
L
F
S
G
F
D
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91875
1642
185391
V276
L
L
K
L
L
V
P
V
L
G
L
S
N
T
D
Honey Bee
Apis mellifera
XP_001121092
1665
190473
F262
I
E
Y
P
T
D
I
F
F
F
E
V
I
P
V
Nematode Worm
Caenorhab. elegans
NP_001022450
1737
195064
F334
G
K
L
L
L
K
L
F
P
M
L
V
D
E
L
Sea Urchin
Strong. purpuratus
XP_794863
1742
194988
E277
D
L
P
S
K
R
G
E
D
S
T
I
D
Q
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P10964
1664
186413
Q336
R
K
E
Q
C
V
L
Q
Y
V
F
H
S
R
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
N.A.
90
N.A.
86.8
87.9
N.A.
N.A.
27
68.1
67.9
N.A.
43.7
43.6
39.3
46.8
Protein Similarity:
100
99.1
N.A.
94.4
N.A.
93.3
93.8
N.A.
N.A.
43.9
81.7
81.3
N.A.
61.4
61.5
57.4
64.4
P-Site Identity:
100
100
N.A.
86.6
N.A.
93.3
93.3
N.A.
N.A.
13.3
6.6
66.6
N.A.
13.3
13.3
0
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
N.A.
33.3
6.6
73.3
N.A.
20
26.6
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
38.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
56.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
8
0
0
8
0
0
0
16
39
47
% D
% Glu:
0
54
16
0
0
0
0
8
0
0
8
0
0
16
0
% E
% Phe:
0
0
0
54
54
8
0
16
16
54
16
0
8
0
8
% F
% Gly:
8
0
47
8
0
0
16
0
0
8
0
47
8
8
0
% G
% His:
0
0
0
0
8
0
0
8
8
0
0
8
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
0
0
0
8
16
8
8
% I
% Lys:
8
16
8
0
8
8
8
0
0
8
0
0
0
0
0
% K
% Leu:
16
16
8
16
16
47
24
0
54
8
16
0
24
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
16
0
8
% M
% Asn:
39
8
0
0
0
0
39
0
0
0
0
0
8
0
0
% N
% Pro:
0
8
8
8
0
0
8
0
8
0
0
0
0
8
8
% P
% Gln:
0
0
0
8
0
0
0
16
0
0
0
0
0
8
0
% Q
% Arg:
8
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
0
8
0
0
0
0
0
8
47
16
8
0
0
% S
% Thr:
8
0
0
0
8
0
0
0
0
0
8
0
0
8
8
% T
% Val:
0
0
0
0
0
24
0
8
0
8
0
24
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
47
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _