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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CNOT4 All Species: 37.27
Human Site: S435 Identified Species: 68.33
UniProt: O95628 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95628 NP_001008226.1 575 63510 S435 Q P S L S P T S L Q N S S S H
Chimpanzee Pan troglodytes XP_001145560 572 63013 S432 Q P S L S P T S L Q N S S S H
Rhesus Macaque Macaca mulatta XP_001105498 572 63013 S432 Q P S L S P T S L Q N S S S H
Dog Lupus familis XP_859452 572 63053 S432 Q P S L S P T S L Q N S S S H
Cat Felis silvestris
Mouse Mus musculus Q8BT14 575 63456 S435 Q P S L S P T S L Q N A S S H
Rat Rattus norvegicus NP_001032871 710 77747 S432 Q P S L S S T S L Q N S S S H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512368 631 69349 S432 Q P S L S P T S L Q N A P S H
Chicken Gallus gallus NP_001012829 762 83565 S484 Q P S L S P T S L Q N P S P H
Frog Xenopus laevis NP_001080612 712 78417 S435 Q P S L S P T S V Q N P N P H
Zebra Danio Brachydanio rerio NP_957463 798 86410 E435 S D W P T A P E P Q S L F T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392724 529 59085 S392 G T Q N N V Q S Q I N G Q K D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780160 657 71694 A433 V Q S I P D L A P P P V T D T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P34909 587 65335 S446 N Y Q K R P I S I K S N I I D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 99.1 98.7 N.A. 98.7 77.4 N.A. 84.4 71.6 72.8 55.3 N.A. N.A. 40.8 N.A. 41.8
Protein Similarity: 100 99.3 99.3 99.1 N.A. 99.1 79.1 N.A. 87 73.3 75.4 61.2 N.A. N.A. 55.8 N.A. 54
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 86.6 86.6 73.3 6.6 N.A. N.A. 13.3 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. 93.3 86.6 86.6 26.6 N.A. N.A. 20 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 8 0 0 0 16 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 8 0 0 0 0 0 0 0 8 16 % D
% Glu: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 70 % H
% Ile: 0 0 0 8 0 0 8 0 8 8 0 0 8 8 0 % I
% Lys: 0 0 0 8 0 0 0 0 0 8 0 0 0 8 0 % K
% Leu: 0 0 0 70 0 0 8 0 62 0 0 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 8 8 0 0 0 0 0 77 8 8 0 0 % N
% Pro: 0 70 0 8 8 70 8 0 16 8 8 16 8 16 0 % P
% Gln: 70 8 16 0 0 0 8 0 8 77 0 0 8 0 0 % Q
% Arg: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 77 0 70 8 0 85 0 0 16 39 54 54 8 % S
% Thr: 0 8 0 0 8 0 70 0 0 0 0 0 8 8 8 % T
% Val: 8 0 0 0 0 8 0 0 8 0 0 8 0 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _