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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CPSF4
All Species:
18.18
Human Site:
Y254
Identified Species:
36.36
UniProt:
O95639
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95639
NP_001075028.1
269
30255
Y254
K
C
G
E
K
G
H
Y
A
N
R
C
T
K
G
Chimpanzee
Pan troglodytes
XP_519234
269
30294
Y254
K
C
G
E
K
G
H
Y
A
N
R
C
T
K
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_850149
269
30210
Y254
K
C
G
E
K
G
H
Y
A
N
R
C
T
K
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8BQZ5
211
23635
A197
C
G
E
K
G
H
Y
A
N
R
C
T
K
G
H
Rat
Rattus norvegicus
Q5FVR7
243
27400
Y228
K
C
G
E
K
G
H
Y
A
N
R
C
T
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512096
280
31237
A266
C
G
E
K
G
H
Y
A
N
R
C
T
K
G
H
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DJP7
269
30474
Y254
K
C
G
E
K
G
H
Y
A
N
R
C
T
K
G
Zebra Danio
Brachydanio rerio
NP_571084
271
30746
G254
C
Y
K
C
G
E
K
G
H
Y
A
N
K
C
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477156
296
33482
F256
S
Q
P
H
G
P
G
F
V
K
V
P
T
P
L
Honey Bee
Apis mellifera
XP_396082
286
32606
K254
T
C
Y
K
C
G
T
K
G
H
Y
A
N
K
C
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q06102
208
24535
E194
I
N
T
R
K
M
D
E
E
K
E
R
R
L
N
Red Bread Mold
Neurospora crassa
Q7SGR2
317
35182
D286
G
G
H
D
R
H
K
D
R
F
G
G
G
G
G
Conservation
Percent
Protein Identity:
100
99.2
N.A.
98.8
N.A.
77.6
89.5
N.A.
83.2
N.A.
90.3
85.2
N.A.
54.3
56.2
N.A.
N.A.
Protein Similarity:
100
99.2
N.A.
98.8
N.A.
77.6
89.5
N.A.
86
N.A.
94.8
90.4
N.A.
66.5
70.2
N.A.
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
0
100
N.A.
0
N.A.
100
0
N.A.
6.6
20
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
13.3
100
N.A.
13.3
N.A.
100
0
N.A.
13.3
33.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33
31.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.8
44.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
17
42
0
9
9
0
0
0
% A
% Cys:
25
50
0
9
9
0
0
0
0
0
17
42
0
9
9
% C
% Asp:
0
0
0
9
0
0
9
9
0
0
0
0
0
0
0
% D
% Glu:
0
0
17
42
0
9
0
9
9
0
9
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
9
0
0
0
0
0
% F
% Gly:
9
25
42
0
34
50
9
9
9
0
9
9
9
25
50
% G
% His:
0
0
9
9
0
25
42
0
9
9
0
0
0
0
17
% H
% Ile:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
42
0
9
25
50
0
17
9
0
17
0
0
25
50
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
9
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
17
42
0
9
9
0
9
% N
% Pro:
0
0
9
0
0
9
0
0
0
0
0
9
0
9
0
% P
% Gln:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
9
9
0
0
0
9
17
42
9
9
0
0
% R
% Ser:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
9
0
9
0
0
0
9
0
0
0
0
17
50
0
9
% T
% Val:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
9
0
0
0
17
42
0
9
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _