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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIRAS3
All Species:
5.45
Human Site:
S154
Identified Species:
10
UniProt:
O95661
Number Species:
12
Phosphosite Substitution
Charge Score:
0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95661
NP_004666.1
229
25861
S154
I
V
L
V
G
N
K
S
D
D
T
H
R
E
V
Chimpanzee
Pan troglodytes
XP_001142084
196
21944
D124
M
L
V
G
N
K
C
D
E
S
L
S
R
E
V
Rhesus Macaque
Macaca mulatta
XP_001095631
228
26121
S154
I
V
L
V
G
N
K
S
D
D
I
H
R
E
V
Dog
Lupus familis
XP_541313
208
23428
D133
M
L
V
G
N
K
C
D
E
S
P
N
R
E
V
Cat
Felis silvestris
Mouse
Mus musculus
Q5PR73
199
22479
D124
M
L
V
G
N
K
C
D
E
S
P
N
R
E
V
Rat
Rattus norvegicus
Q62636
184
20779
I112
D
T
D
D
V
P
M
I
L
V
G
N
K
C
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513649
198
22370
S126
V
G
N
K
S
D
E
S
Q
R
E
L
D
A
G
Chicken
Gallus gallus
XP_423026
199
22563
D124
M
L
V
G
N
K
N
D
E
N
Q
N
R
E
V
Frog
Xenopus laevis
Q7ZXH7
184
20815
I112
D
T
D
D
V
P
M
I
L
V
G
N
K
C
D
Zebra Danio
Brachydanio rerio
Q6TEN1
184
20809
I112
D
T
D
D
V
P
M
I
L
V
G
N
K
C
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08645
184
20845
V112
D
T
D
D
V
P
M
V
L
V
G
N
K
C
D
Honey Bee
Apis mellifera
XP_001121695
205
22930
E126
L
V
G
N
K
C
D
E
S
P
S
V
R
E
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780973
198
22635
P126
V
G
N
K
C
D
D
P
N
R
E
V
S
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.4
91.6
43.2
N.A.
42.3
24.4
N.A.
44.5
43.6
24.4
24.8
N.A.
26.2
36.6
N.A.
41.9
Protein Similarity:
100
55.9
95.6
60.7
N.A.
58.5
42.3
N.A.
59.8
59.3
42.3
42.3
N.A.
44.5
56.7
N.A.
59.3
P-Site Identity:
100
20
93.3
20
N.A.
20
0
N.A.
6.6
20
0
0
N.A.
0
26.6
N.A.
0
P-Site Similarity:
100
46.6
93.3
53.3
N.A.
53.3
13.3
N.A.
26.6
60
13.3
13.3
N.A.
13.3
40
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
8
8
24
0
0
0
0
0
0
31
0
% C
% Asp:
31
0
31
31
0
16
16
31
16
16
0
0
8
0
31
% D
% Glu:
0
0
0
0
0
0
8
8
31
0
16
0
0
54
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
16
8
31
16
0
0
0
0
0
31
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% H
% Ile:
16
0
0
0
0
0
0
24
0
0
8
0
0
8
0
% I
% Lys:
0
0
0
16
8
31
16
0
0
0
0
0
31
0
0
% K
% Leu:
8
31
16
0
0
0
0
0
31
0
8
8
0
0
0
% L
% Met:
31
0
0
0
0
0
31
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
16
8
31
16
8
0
8
8
0
54
0
0
0
% N
% Pro:
0
0
0
0
0
31
0
8
0
8
16
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
16
0
0
54
0
0
% R
% Ser:
0
0
0
0
8
0
0
24
8
24
8
8
8
0
0
% S
% Thr:
0
31
0
0
0
0
0
0
0
0
8
0
0
0
0
% T
% Val:
16
24
31
16
31
0
0
8
0
31
0
16
0
0
54
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _