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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDS2 All Species: 40.3
Human Site: S255 Identified Species: 73.89
UniProt: O95674 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95674 NP_003809.1 445 51418 S255 R T P L I K L S P K K T W E G
Chimpanzee Pan troglodytes XP_001165937 445 51414 S255 R T P L I K L S P K K T W E G
Rhesus Macaque Macaca mulatta XP_001104375 460 52839 S271 R T P L I K L S P K K T W E G
Dog Lupus familis XP_542903 454 52058 S264 R T P L I K L S P K K T W E G
Cat Felis silvestris
Mouse Mus musculus Q99L43 444 51295 S254 R T P L I K L S P K K T W E G
Rat Rattus norvegicus Q91XU8 443 51304 S254 R T P L I K L S P K K T W E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513442 748 84077 S369 R T P L I K L S P K K T W E G
Chicken Gallus gallus XP_417669 448 51740 S259 R T P L I K L S P K K T W E G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_957480 444 51048 S254 R T P L I K L S P K K T W E G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P56079 447 51493 G257 D V M A Y V F G F F F G R T P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P53439 455 52423 P266 G F F W G K T P L I K L S P K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04928 421 48641 R232 I F G F F F G R T P L I K L S
Baker's Yeast Sacchar. cerevisiae P38221 457 51804 S248 K T K L I E I S P K K T L E G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 67.3 92.2 N.A. 96.1 94.6 N.A. 44.6 90.1 N.A. 81.5 N.A. 59.5 N.A. 51.8 N.A.
Protein Similarity: 100 99.7 80.6 93.1 N.A. 97.3 96.8 N.A. 51.2 94.6 N.A. 90.7 N.A. 74.2 N.A. 66.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 N.A. 100 N.A. 0 N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 N.A. 100 N.A. 0 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 34.3 35.2 N.A.
Protein Similarity: N.A. N.A. N.A. 54.3 54.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 0 0 0 77 0 % E
% Phe: 0 16 8 8 8 8 8 0 8 8 8 0 0 0 0 % F
% Gly: 8 0 8 0 8 0 8 8 0 0 0 8 0 0 77 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 77 0 8 0 0 8 0 8 0 0 0 % I
% Lys: 8 0 8 0 0 77 0 0 0 77 85 0 8 0 8 % K
% Leu: 0 0 0 77 0 0 70 0 8 0 8 8 8 8 0 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 70 0 0 0 0 8 77 8 0 0 0 8 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 70 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % R
% Ser: 0 0 0 0 0 0 0 77 0 0 0 0 8 0 8 % S
% Thr: 0 77 0 0 0 0 8 0 8 0 0 77 0 8 0 % T
% Val: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 0 0 70 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _