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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EYA4
All Species:
9.09
Human Site:
S346
Identified Species:
22.22
UniProt:
O95677
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95677
NP_004091.3
639
69505
S346
L
D
E
R
T
C
R
S
S
G
S
K
S
R
G
Chimpanzee
Pan troglodytes
XP_001169695
645
70123
D346
S
T
P
I
K
D
L
D
E
R
T
C
R
S
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_541108
468
51448
V202
S
D
L
E
R
V
F
V
W
D
L
D
E
T
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z191
616
66872
E346
P
P
P
D
S
D
L
E
R
V
F
V
W
D
L
Rat
Rattus norvegicus
XP_217715
884
96614
S591
L
D
D
R
T
C
R
S
S
G
S
K
S
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506770
633
68678
R346
R
N
S
G
S
K
S
R
G
R
G
R
K
N
N
Chicken
Gallus gallus
XP_419735
639
69329
S346
L
D
E
R
T
C
R
S
S
G
S
K
S
R
G
Frog
Xenopus laevis
NP_001083888
592
64622
I326
S
D
L
E
R
V
F
I
W
D
L
D
E
T
I
Zebra Danio
Brachydanio rerio
NP_571268
609
66497
I343
S
D
L
E
R
V
F
I
W
D
L
D
E
T
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05201
766
80638
H470
G
R
A
R
G
R
R
H
Q
Q
P
S
P
T
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
N.A.
70.5
N.A.
91.2
69
N.A.
92.1
94.2
67.6
69
N.A.
36.6
N.A.
N.A.
N.A.
Protein Similarity:
100
98.9
N.A.
71.6
N.A.
93.4
70.3
N.A.
95.3
96.5
77.6
80.7
N.A.
52.8
N.A.
N.A.
N.A.
P-Site Identity:
100
0
N.A.
6.6
N.A.
0
93.3
N.A.
0
100
6.6
6.6
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
6.6
N.A.
6.6
N.A.
6.6
100
N.A.
20
100
6.6
6.6
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
30
0
0
0
0
0
10
0
0
0
% C
% Asp:
0
60
10
10
0
20
0
10
0
30
0
30
0
10
0
% D
% Glu:
0
0
20
30
0
0
0
10
10
0
0
0
30
0
0
% E
% Phe:
0
0
0
0
0
0
30
0
0
0
10
0
0
0
0
% F
% Gly:
10
0
0
10
10
0
0
0
10
30
10
0
0
0
30
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
20
0
0
0
0
0
0
30
% I
% Lys:
0
0
0
0
10
10
0
0
0
0
0
30
10
0
0
% K
% Leu:
30
0
30
0
0
0
20
0
0
0
30
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
10
10
% N
% Pro:
10
10
20
0
0
0
0
0
0
0
10
0
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% Q
% Arg:
10
10
0
40
30
10
40
10
10
20
0
10
10
30
10
% R
% Ser:
40
0
10
0
20
0
10
30
30
0
30
10
30
10
10
% S
% Thr:
0
10
0
0
30
0
0
0
0
0
10
0
0
40
0
% T
% Val:
0
0
0
0
0
30
0
10
0
10
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
30
0
0
0
10
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _