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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSPA4L
All Species:
28.48
Human Site:
S336
Identified Species:
44.76
UniProt:
O95757
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95757
NP_055093.2
839
94486
S336
N
L
Q
R
E
D
I
S
S
I
E
I
V
G
G
Chimpanzee
Pan troglodytes
XP_001157094
840
94684
S336
N
L
Q
R
E
D
I
S
S
I
E
I
V
G
G
Rhesus Macaque
Macaca mulatta
XP_001106968
840
94362
Y336
K
L
K
K
E
D
I
Y
A
V
E
I
V
G
G
Dog
Lupus familis
XP_533297
840
94621
S336
N
L
Q
R
E
D
I
S
S
I
E
I
V
G
G
Cat
Felis silvestris
Mouse
Mus musculus
P48722
838
94364
N336
N
L
Q
R
E
D
I
N
S
I
E
I
V
G
G
Rat
Rattus norvegicus
O88600
840
94038
Y336
K
L
K
K
E
D
I
Y
A
V
E
I
V
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510127
834
93982
Y330
K
L
K
K
E
D
I
Y
A
V
E
I
V
G
G
Chicken
Gallus gallus
NP_001012594
843
94794
Y336
K
L
Q
R
E
D
I
Y
S
I
E
I
V
G
G
Frog
Xenopus laevis
P02827
647
70897
K188
A
I
A
Y
G
L
D
K
G
A
R
G
E
Q
N
Zebra Danio
Brachydanio rerio
XP_690505
826
93290
Y336
K
L
S
R
D
E
I
Y
A
I
E
V
V
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VG58
641
70235
L182
A
A
A
L
A
Y
G
L
D
K
N
L
K
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q05036
776
86878
I315
F
E
D
L
A
A
P
I
F
N
R
I
K
Q
V
Sea Urchin
Strong. purpuratus
Q06068
889
98600
H336
K
L
K
P
E
D
I
H
S
I
E
I
V
G
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32590
693
77602
G234
A
Y
D
K
H
F
G
G
R
D
F
D
R
A
I
Red Bread Mold
Neurospora crassa
O74225
707
78655
L248
D
H
L
H
K
E
F
L
G
K
Y
K
I
D
I
Conservation
Percent
Protein Identity:
100
99.2
63.8
95.9
N.A.
92.6
63.3
N.A.
60.1
81.6
28.7
65.7
N.A.
28
N.A.
43
49.6
Protein Similarity:
100
99.4
79.2
98.3
N.A.
96.5
79
N.A.
75.9
91.4
47.2
81.6
N.A.
46.9
N.A.
58.8
67.9
P-Site Identity:
100
100
60
100
N.A.
93.3
60
N.A.
60
86.6
0
53.3
N.A.
0
N.A.
6.6
73.3
P-Site Similarity:
100
100
86.6
100
N.A.
100
86.6
N.A.
86.6
86.6
6.6
80
N.A.
6.6
N.A.
6.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.8
38.3
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.2
55.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
7
14
0
14
7
0
0
27
7
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
14
0
7
60
7
0
7
7
0
7
0
14
0
% D
% Glu:
0
7
0
0
60
14
0
0
0
0
67
0
7
0
7
% E
% Phe:
7
0
0
0
0
7
7
0
7
0
7
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
14
7
14
0
0
7
0
67
67
% G
% His:
0
7
0
7
7
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
67
7
0
47
0
67
7
0
14
% I
% Lys:
40
0
27
27
7
0
0
7
0
14
0
7
14
0
0
% K
% Leu:
0
67
7
14
0
7
0
14
0
0
0
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
27
0
0
0
0
0
0
7
0
7
7
0
0
0
7
% N
% Pro:
0
0
0
7
0
0
7
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
34
0
0
0
0
0
0
0
0
0
0
14
0
% Q
% Arg:
0
0
0
40
0
0
0
0
7
0
14
0
7
0
0
% R
% Ser:
0
0
7
0
0
0
0
20
40
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
20
0
7
67
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
7
0
7
0
34
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _