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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTC4 All Species: 26.36
Human Site: T141 Identified Species: 38.67
UniProt: O95801 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95801 NP_004614.3 387 44679 T141 R S A L N D V T A A R K L K P
Chimpanzee Pan troglodytes XP_001153260 387 44743 T141 C S A L N D V T A A R K L K P
Rhesus Macaque Macaca mulatta XP_001114145 387 44737 T141 R S A L N D V T A A R K L K P
Dog Lupus familis XP_853176 358 40916 T170 K A D K L K R T E Q R D I R K
Cat Felis silvestris
Mouse Mus musculus Q8R3H9 386 44320 L141 R S S L N D V L A A K K L K P
Rat Rattus norvegicus NP_001013232 237 27309 D70 C L Q S I I F D D E R S P E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519382 216 24029 A49 R T P L A A Q A G G R R A G Q
Chicken Gallus gallus XP_426665 313 35720 K140 K L K P D H L K A V V R G A L
Frog Xenopus laevis NP_001085211 384 44859 T137 R S A L N D A T A A R K L K P
Zebra Danio Brachydanio rerio NP_001002122 402 46052 T141 R S A L N D A T A A K K L K P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_525106 396 46888 Q153 R S S L S D A Q R A L F Y K P
Honey Bee Apis mellifera XP_624121 332 39077 K154 R S S L N D C K L A L K L K S
Nematode Worm Caenorhab. elegans NP_495087 419 49032 S157 R S A I K D C S M G R K F D P
Sea Urchin Strong. purpuratus XP_791465 364 41863 K147 R S S L N D A K E A L N L K P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P33313 385 44094 S145 R R C I E D C S K A L T I N P
Red Bread Mold Neurospora crassa P23231 624 69413 T227 R H A L L D F T A S C I I D G
Conservation
Percent
Protein Identity: 100 98.1 97.1 80.8 N.A. 82.4 53.2 N.A. 32 50.9 59.6 57.4 N.A. 31.3 36.6 30.7 42.1
Protein Similarity: 100 98.7 98.7 87.8 N.A. 90.4 57.8 N.A. 40 64.3 76.7 74.1 N.A. 51 55 47.9 61.5
P-Site Identity: 100 93.3 100 13.3 N.A. 80 6.6 N.A. 20 6.6 93.3 86.6 N.A. 46.6 60 46.6 60
P-Site Similarity: 100 93.3 100 40 N.A. 93.3 13.3 N.A. 33.3 33.3 93.3 93.3 N.A. 60 66.6 60 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.7 20.3
Protein Similarity: N.A. N.A. N.A. N.A. 43.9 34.9
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 40
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 44 0 7 7 25 7 50 63 0 0 7 7 0 % A
% Cys: 13 0 7 0 0 0 19 0 0 0 7 0 0 0 0 % C
% Asp: 0 0 7 0 7 75 0 7 7 0 0 7 0 13 0 % D
% Glu: 0 0 0 0 7 0 0 0 13 7 0 0 0 7 7 % E
% Phe: 0 0 0 0 0 0 13 0 0 0 0 7 7 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 7 13 0 0 7 7 7 % G
% His: 0 7 0 0 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 13 7 7 0 0 0 0 0 7 19 0 0 % I
% Lys: 13 0 7 7 7 7 0 19 7 0 13 50 0 57 7 % K
% Leu: 0 13 0 69 13 0 7 7 7 0 25 0 50 0 7 % L
% Met: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 50 0 0 0 0 0 0 7 0 7 0 % N
% Pro: 0 0 7 7 0 0 0 0 0 0 0 0 7 0 63 % P
% Gln: 0 0 7 0 0 0 7 7 0 7 0 0 0 0 7 % Q
% Arg: 75 7 0 0 0 0 7 0 7 0 50 13 0 7 0 % R
% Ser: 0 63 25 7 7 0 0 13 0 7 0 7 0 0 7 % S
% Thr: 0 7 0 0 0 0 0 44 0 0 0 7 0 0 0 % T
% Val: 0 0 0 0 0 0 25 0 0 7 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _