KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP4K4
All Species:
3.03
Human Site:
T774
Identified Species:
7.41
UniProt:
O95819
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95819
NP_004825.2
1239
142101
T774
S
S
E
E
S
G
T
T
D
E
E
D
D
D
V
Chimpanzee
Pan troglodytes
XP_001164484
1218
139980
E753
E
S
E
S
S
E
E
E
E
E
D
G
E
S
E
Rhesus Macaque
Macaca mulatta
A4K2T0
487
55587
K50
S
V
Y
K
A
I
H
K
E
T
G
Q
I
V
A
Dog
Lupus familis
XP_862255
1297
148103
S832
S
H
A
D
T
F
S
S
S
I
S
R
E
G
T
Cat
Felis silvestris
Mouse
Mus musculus
P83510
1323
150348
G858
S
H
A
D
T
F
G
G
S
I
S
R
E
G
T
Rat
Rattus norvegicus
Q924I2
873
98660
G436
S
S
E
D
S
N
Q
G
T
I
K
R
C
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJK4
486
55318
K49
S
V
F
K
A
I
H
K
E
T
G
Q
V
V
A
Frog
Xenopus laevis
Q6PA14
485
55246
S48
Y
G
S
V
Y
K
A
S
H
K
E
T
S
Q
I
Zebra Danio
Brachydanio rerio
Q7ZUQ3
492
56062
K55
S
G
Q
V
V
A
I
K
Q
V
P
V
E
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23356
1096
122486
I626
I
P
E
I
R
P
G
I
I
S
L
D
D
D
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.6
20.8
63.8
N.A.
65.3
25.5
N.A.
N.A.
20.9
20
21.2
N.A.
N.A.
N.A.
49.4
N.A.
Protein Similarity:
100
82.8
29
74.1
N.A.
75.4
40.7
N.A.
N.A.
28.9
28.8
29.7
N.A.
N.A.
N.A.
62.6
N.A.
P-Site Identity:
100
26.6
6.6
6.6
N.A.
6.6
26.6
N.A.
N.A.
6.6
6.6
6.6
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
100
46.6
26.6
40
N.A.
26.6
40
N.A.
N.A.
26.6
26.6
20
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
20
0
20
10
10
0
0
0
0
0
0
0
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
0
30
0
0
0
0
10
0
10
20
20
20
20
% D
% Glu:
10
0
40
10
0
10
10
10
30
20
20
0
40
0
10
% E
% Phe:
0
0
10
0
0
20
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
20
0
0
0
10
20
20
0
0
20
10
0
20
0
% G
% His:
0
20
0
0
0
0
20
0
10
0
0
0
0
0
0
% H
% Ile:
10
0
0
10
0
20
10
10
10
30
0
0
10
0
10
% I
% Lys:
0
0
0
20
0
10
0
30
0
10
10
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
0
0
10
0
0
0
0
10
0
0
10
0
% P
% Gln:
0
0
10
0
0
0
10
0
10
0
0
20
0
10
0
% Q
% Arg:
0
0
0
0
10
0
0
0
0
0
0
30
0
0
0
% R
% Ser:
70
30
10
10
30
0
10
20
20
10
20
0
10
20
10
% S
% Thr:
0
0
0
0
20
0
10
10
10
20
0
10
0
0
20
% T
% Val:
0
20
0
20
10
0
0
0
0
10
0
10
10
20
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _