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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLYCD All Species: 24.55
Human Site: S380 Identified Species: 41.54
UniProt: O95822 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95822 NP_036345.2 493 55003 S380 E T L K L L L S S S E W V Q S
Chimpanzee Pan troglodytes XP_523518 493 54957 S380 E T L K L L L S S S E W V Q S
Rhesus Macaque Macaca mulatta XP_001112117 493 54893 G380 E T L K L L L G S S E W V Q S
Dog Lupus familis XP_852152 442 48705 S329 E T L K V L L S S S E W I K S
Cat Felis silvestris
Mouse Mus musculus Q99J39 492 54718 S379 E S L K G F L S S G E W V K S
Rat Rattus norvegicus Q920F5 492 54744 S379 E S L K G L L S S G E W A K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508710 449 50992 T336 E T L K V L L T S N E W V K S
Chicken Gallus gallus XP_414174 547 60873 N434 E T L K K L L N N N E W V R S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001082972 504 57530 S391 E A L R R L I S T S E W I H S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_625201 377 44289 K276 S L W T H N I K I S E V L K K
Nematode Worm Caenorhab. elegans NP_001022561 442 50154 V338 A T E T L L K V I S N E K T K
Sea Urchin Strong. purpuratus XP_001184115 408 46014 D307 L F T S Q E L D S F K S A L N
Poplar Tree Populus trichocarpa XP_002331555 468 52961 N330 D E E R M L L N S A L E T Y A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_192341 518 58433 L393 E E H A L M T L S D E S S S G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 96.5 74.8 N.A. 88 88.2 N.A. 67.7 65 N.A. 58.3 N.A. N.A. 39.7 34.8 41.7
Protein Similarity: 100 98.9 97.3 80.7 N.A. 91.8 92.4 N.A. 76.2 75.5 N.A. 71.6 N.A. N.A. 53.9 51.3 54.9
P-Site Identity: 100 100 93.3 80 N.A. 66.6 66.6 N.A. 73.3 66.6 N.A. 53.3 N.A. N.A. 13.3 26.6 13.3
P-Site Similarity: 100 100 93.3 100 N.A. 80 80 N.A. 100 93.3 N.A. 80 N.A. N.A. 33.3 26.6 26.6
Percent
Protein Identity: 38.1 N.A. N.A. 37.4 N.A. N.A.
Protein Similarity: 54.1 N.A. N.A. 53.8 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: 60 N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 0 0 0 0 0 8 0 0 15 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % D
% Glu: 72 15 15 0 0 8 0 0 0 0 79 15 0 0 0 % E
% Phe: 0 8 0 0 0 8 0 0 0 8 0 0 0 0 0 % F
% Gly: 0 0 0 0 15 0 0 8 0 15 0 0 0 0 8 % G
% His: 0 0 8 0 8 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 0 0 15 0 15 0 0 0 15 0 0 % I
% Lys: 0 0 0 58 8 0 8 8 0 0 8 0 8 36 15 % K
% Leu: 8 8 65 0 36 72 72 8 0 0 8 0 8 8 0 % L
% Met: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 15 8 15 8 0 0 0 8 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 8 0 0 0 0 0 0 0 0 22 0 % Q
% Arg: 0 0 0 15 8 0 0 0 0 0 0 0 0 8 0 % R
% Ser: 8 15 0 8 0 0 0 43 72 50 0 15 8 8 65 % S
% Thr: 0 50 8 15 0 0 8 8 8 0 0 0 8 8 0 % T
% Val: 0 0 0 0 15 0 0 8 0 0 0 8 43 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 65 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _