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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ECD
All Species:
15.45
Human Site:
S335
Identified Species:
28.33
UniProt:
O95905
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95905
NP_001129225.1
644
72758
S335
T
A
S
P
L
W
A
S
F
L
E
S
L
K
K
Chimpanzee
Pan troglodytes
XP_508169
648
72940
S335
T
A
S
P
L
W
A
S
F
L
E
S
L
K
K
Rhesus Macaque
Macaca mulatta
XP_001103459
644
72818
S335
T
A
S
P
L
W
A
S
F
L
A
S
L
K
K
Dog
Lupus familis
XP_536386
643
72587
G335
T
T
S
P
L
W
A
G
F
L
E
S
L
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9CS74
641
71691
S335
T
A
S
P
L
W
A
S
F
L
E
S
L
K
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508376
598
66758
A297
R
S
H
P
Q
Y
R
A
H
E
L
G
M
K
L
Chicken
Gallus gallus
XP_421522
638
71575
R330
F
R
G
P
L
W
E
R
Y
L
H
S
L
K
E
Frog
Xenopus laevis
NP_001088274
642
71779
G333
L
Q
T
P
Q
W
T
G
F
L
N
A
L
K
K
Zebra Danio
Brachydanio rerio
XP_002665219
632
70256
G333
S
S
N
P
L
W
R
G
F
L
E
S
L
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W032
684
77889
S355
E
D
L
P
A
W
R
S
Y
L
R
S
L
L
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786801
567
62710
V273
I
M
K
L
L
E
T
V
H
C
D
I
T
Q
L
Poplar Tree
Populus trichocarpa
XP_002326322
639
72489
K325
G
K
G
S
T
W
L
K
Y
K
E
S
L
E
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LSM5
643
73143
K330
G
K
G
I
S
W
S
K
Y
K
D
N
L
E
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.3
95.9
86.6
N.A.
78.4
N.A.
N.A.
59.4
59.3
60
52.6
N.A.
29.6
N.A.
N.A.
21.2
Protein Similarity:
100
97.3
97.9
92.6
N.A.
89.1
N.A.
N.A.
73.1
72.9
75.6
69.8
N.A.
49.5
N.A.
N.A.
36.6
P-Site Identity:
100
100
93.3
86.6
N.A.
93.3
N.A.
N.A.
13.3
46.6
46.6
66.6
N.A.
40
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
86.6
N.A.
100
N.A.
N.A.
40
60
60
86.6
N.A.
46.6
N.A.
N.A.
20
Percent
Protein Identity:
34
N.A.
N.A.
35.4
N.A.
N.A.
Protein Similarity:
55.2
N.A.
N.A.
53.8
N.A.
N.A.
P-Site Identity:
26.6
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
31
0
0
8
0
39
8
0
0
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
16
0
0
0
0
% D
% Glu:
8
0
0
0
0
8
8
0
0
8
47
0
0
16
8
% E
% Phe:
8
0
0
0
0
0
0
0
54
0
0
0
0
0
0
% F
% Gly:
16
0
24
0
0
0
0
24
0
0
0
8
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
16
0
8
0
0
0
0
% H
% Ile:
8
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
16
8
0
0
0
0
16
0
16
0
0
0
70
54
% K
% Leu:
8
0
8
8
62
0
8
0
0
70
8
0
85
8
16
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
8
8
0
0
0
% N
% Pro:
0
0
0
77
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
16
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
8
8
0
0
0
0
24
8
0
0
8
0
0
0
16
% R
% Ser:
8
16
39
8
8
0
8
39
0
0
0
70
0
0
8
% S
% Thr:
39
8
8
0
8
0
16
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
85
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
31
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _