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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ECD All Species: 25.76
Human Site: Y38 Identified Species: 47.22
UniProt: O95905 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95905 NP_001129225.1 644 72758 Y38 H K E I L Q K Y I E R I I T R
Chimpanzee Pan troglodytes XP_508169 648 72940 Y38 H K E I L Q K Y I E R I M T Q
Rhesus Macaque Macaca mulatta XP_001103459 644 72818 Y38 H E E V L Q K Y I E R I M T R
Dog Lupus familis XP_536386 643 72587 Y38 H K E I L Q K Y I E R I M T Q
Cat Felis silvestris
Mouse Mus musculus Q9CS74 641 71691 Y38 H R E I L Q K Y I E R I M T Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508376 598 66758 Y38 C T G V L Q Q Y I E K I M T Q
Chicken Gallus gallus XP_421522 638 71575 A38 R R C A D G I A V R L A P L L
Frog Xenopus laevis NP_001088274 642 71779 Y38 E K K I L Q E Y I E R I L A K
Zebra Danio Brachydanio rerio XP_002665219 632 70256 D40 S L Q Q I L Q D I L A E I T P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W032 684 77889 H63 L E R S Y L W H K D E F Q L Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786801 567 62710 K19 G E L H I I P K P G S P A E L
Poplar Tree Populus trichocarpa XP_002326322 639 72489 L39 A S S Q S L H L Y L Q I L D F
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LSM5 643 73143 I45 Q S L H L E I I D F V S P F T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.3 95.9 86.6 N.A. 78.4 N.A. N.A. 59.4 59.3 60 52.6 N.A. 29.6 N.A. N.A. 21.2
Protein Similarity: 100 97.3 97.9 92.6 N.A. 89.1 N.A. N.A. 73.1 72.9 75.6 69.8 N.A. 49.5 N.A. N.A. 36.6
P-Site Identity: 100 86.6 80 86.6 N.A. 80 N.A. N.A. 46.6 0 60 20 N.A. 0 N.A. N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 80 13.3 86.6 40 N.A. 26.6 N.A. N.A. 13.3
Percent
Protein Identity: 34 N.A. N.A. 35.4 N.A. N.A.
Protein Similarity: 55.2 N.A. N.A. 53.8 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 0 0 0 8 0 0 8 8 8 8 0 % A
% Cys: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 8 8 8 0 0 0 8 0 % D
% Glu: 8 24 39 0 0 8 8 0 0 54 8 8 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 8 0 8 8 % F
% Gly: 8 0 8 0 0 8 0 0 0 8 0 0 0 0 0 % G
% His: 39 0 0 16 0 0 8 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 39 16 8 16 8 62 0 0 62 16 0 0 % I
% Lys: 0 31 8 0 0 0 39 8 8 0 8 0 0 0 8 % K
% Leu: 8 8 16 0 62 24 0 8 0 16 8 0 16 16 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 39 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 8 0 8 0 0 8 16 0 8 % P
% Gln: 8 0 8 16 0 54 16 0 0 0 8 0 8 0 39 % Q
% Arg: 8 16 8 0 0 0 0 0 0 8 47 0 0 0 16 % R
% Ser: 8 16 8 8 8 0 0 0 0 0 8 8 0 0 0 % S
% Thr: 0 8 0 0 0 0 0 0 0 0 0 0 0 54 8 % T
% Val: 0 0 0 16 0 0 0 0 8 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 54 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _