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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3B All Species: 27.27
Human Site: S395 Identified Species: 50
UniProt: O95985 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95985 NP_003926.1 862 96662 S395 P P I T P M K S A T E A E L G
Chimpanzee Pan troglodytes XP_515006 956 106787 S489 P P I T P M K S A T E A E L G
Rhesus Macaque Macaca mulatta XP_001089027 862 96675 S395 P P I T P M K S A T E A E L G
Dog Lupus familis XP_534771 862 96765 S395 P P I T P M R S A T E A E L G
Cat Felis silvestris
Mouse Mus musculus Q9Z321 862 96931 S395 P P I T P M K S A T E A E L G
Rat Rattus norvegicus NP_001099331 862 96832 S395 P P I T P M K S A T E A E L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006181 862 96669 A395 P P I T P M K A A T E V E L G
Frog Xenopus laevis NP_001082554 858 96526 S395 P P I T P M R S A T E S E L G
Zebra Danio Brachydanio rerio XP_002662012 861 96385 A395 P P I T P M R A A S E N E L G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96651 875 96955 L390 P P I T P M K L G N R S D F D
Honey Bee Apis mellifera XP_625165 851 95935 H393 P P I T P M K H A T R N E L D
Nematode Worm Caenorhab. elegans O61660 759 85420 P343 R T E T N K F P A G L N L T P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13099 656 74352 V242 Q F P T L G F V V D R F E R I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90 99.1 95.7 N.A. 95.5 94.6 N.A. N.A. 87.4 86.1 82.3 N.A. 57.2 64.3 30.5 N.A.
Protein Similarity: 100 90.1 99.7 97.5 N.A. 97.8 97.6 N.A. N.A. 93.9 93.2 91 N.A. 70 78.3 46.7 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. 86.6 86.6 73.3 N.A. 46.6 73.3 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 93.3 100 93.3 N.A. 60 73.3 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 16 85 0 0 47 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 16 % D
% Glu: 0 0 8 0 0 0 0 0 0 0 70 0 85 0 0 % E
% Phe: 0 8 0 0 0 0 16 0 0 0 0 8 0 8 0 % F
% Gly: 0 0 0 0 0 8 0 0 8 8 0 0 0 0 70 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 85 0 0 0 0 0 0 0 0 0 0 0 8 % I
% Lys: 0 0 0 0 0 8 62 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 8 0 0 8 0 0 8 0 8 77 0 % L
% Met: 0 0 0 0 0 85 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 8 0 24 0 0 0 % N
% Pro: 85 85 8 0 85 0 0 8 0 0 0 0 0 0 8 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 0 0 0 0 24 0 0 0 24 0 0 8 0 % R
% Ser: 0 0 0 0 0 0 0 54 0 8 0 16 0 0 0 % S
% Thr: 0 8 0 100 0 0 0 0 0 70 0 0 0 8 0 % T
% Val: 0 0 0 0 0 0 0 8 8 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _