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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3B
All Species:
33.03
Human Site:
T44
Identified Species:
60.56
UniProt:
O95985
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95985
NP_003926.1
862
96662
T44
S
V
H
E
Y
T
G
T
F
A
G
Q
P
V
R
Chimpanzee
Pan troglodytes
XP_515006
956
106787
T138
S
V
H
E
Y
T
G
T
F
A
G
Q
P
V
R
Rhesus Macaque
Macaca mulatta
XP_001089027
862
96675
T44
S
V
H
E
Y
T
G
T
F
A
G
Q
P
V
R
Dog
Lupus familis
XP_534771
862
96765
T44
S
V
H
E
Y
S
G
T
F
A
G
Q
P
V
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z321
862
96931
T44
S
V
H
K
Y
T
G
T
F
A
G
Q
P
V
H
Rat
Rattus norvegicus
NP_001099331
862
96832
T44
S
V
H
K
Y
T
G
T
F
A
G
Q
P
V
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006181
862
96669
S44
S
V
H
E
Y
T
G
S
F
I
G
Q
S
A
H
Frog
Xenopus laevis
NP_001082554
858
96526
S44
S
V
H
E
Y
T
G
S
F
M
G
Q
N
V
R
Zebra Danio
Brachydanio rerio
XP_002662012
861
96385
S44
S
V
H
E
Y
M
G
S
F
T
G
Q
N
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96651
875
96955
N44
S
T
H
E
W
T
G
N
F
R
N
E
G
S
V
Honey Bee
Apis mellifera
XP_625165
851
95935
Q44
S
V
H
E
W
I
G
Q
F
R
S
E
T
V
N
Nematode Worm
Caenorhab. elegans
O61660
759
85420
E44
K
I
Y
T
L
N
T
E
L
F
G
Q
Q
T
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13099
656
74352
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90
99.1
95.7
N.A.
95.5
94.6
N.A.
N.A.
87.4
86.1
82.3
N.A.
57.2
64.3
30.5
N.A.
Protein Similarity:
100
90.1
99.7
97.5
N.A.
97.8
97.6
N.A.
N.A.
93.9
93.2
91
N.A.
70
78.3
46.7
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
N.A.
66.6
80
73.3
N.A.
40
46.6
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
73.3
86.6
80
N.A.
53.3
60
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
47
0
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
70
0
0
0
8
0
0
0
16
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
85
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
85
0
0
0
77
0
8
0
0
% G
% His:
0
0
85
0
0
0
0
0
0
0
0
0
0
0
24
% H
% Ile:
0
8
0
0
0
8
0
0
0
8
0
0
0
0
0
% I
% Lys:
8
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
8
0
0
8
0
16
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
47
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
0
77
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
47
% R
% Ser:
85
0
0
0
0
8
0
24
0
0
8
0
8
8
0
% S
% Thr:
0
8
0
8
0
62
8
47
0
8
0
0
8
8
0
% T
% Val:
0
77
0
0
0
0
0
0
0
0
0
0
0
70
8
% V
% Trp:
0
0
0
0
16
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
70
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _