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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3B
All Species:
43.64
Human Site:
Y344
Identified Species:
80
UniProt:
O95985
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95985
NP_003926.1
862
96662
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Chimpanzee
Pan troglodytes
XP_515006
956
106787
Y438
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Rhesus Macaque
Macaca mulatta
XP_001089027
862
96675
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Dog
Lupus familis
XP_534771
862
96765
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z321
862
96931
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Rat
Rattus norvegicus
NP_001099331
862
96832
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006181
862
96669
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Frog
Xenopus laevis
NP_001082554
858
96526
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Zebra Danio
Brachydanio rerio
XP_002662012
861
96385
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96651
875
96955
Y340
P
R
T
E
T
N
Q
Y
P
T
N
F
D
L
P
Honey Bee
Apis mellifera
XP_625165
851
95935
Y342
P
R
T
E
T
T
L
Y
P
E
N
F
D
L
L
Nematode Worm
Caenorhab. elegans
O61660
759
85420
V302
R
P
Q
A
L
D
T
V
E
L
E
K
L
G
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13099
656
74352
L201
T
R
L
L
T
E
T
L
R
N
K
L
R
N
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90
99.1
95.7
N.A.
95.5
94.6
N.A.
N.A.
87.4
86.1
82.3
N.A.
57.2
64.3
30.5
N.A.
Protein Similarity:
100
90.1
99.7
97.5
N.A.
97.8
97.6
N.A.
N.A.
93.9
93.2
91
N.A.
70
78.3
46.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
73.3
86.6
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
73.3
86.6
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
0
0
0
0
0
85
0
0
% D
% Glu:
0
0
0
85
0
8
0
0
8
77
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
85
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
70
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
70
% K
% Leu:
0
0
8
8
8
0
8
8
0
8
0
8
8
85
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
8
85
0
0
8
0
% N
% Pro:
85
8
0
0
0
0
0
0
85
0
0
0
0
0
8
% P
% Gln:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
8
% Q
% Arg:
8
93
0
0
0
0
0
0
8
0
0
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
8
0
85
0
93
77
16
0
0
8
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
85
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _