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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3B
All Species:
43.33
Human Site:
Y493
Identified Species:
79.44
UniProt:
O95985
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95985
NP_003926.1
862
96662
Y493
K
Q
T
N
P
P
D
Y
L
T
E
A
E
L
I
Chimpanzee
Pan troglodytes
XP_515006
956
106787
Y587
K
Q
T
N
P
P
D
Y
L
T
E
A
E
L
I
Rhesus Macaque
Macaca mulatta
XP_001089027
862
96675
Y493
K
Q
T
S
P
P
D
Y
L
T
E
A
E
L
I
Dog
Lupus familis
XP_534771
862
96765
Y493
K
Q
T
S
P
P
D
Y
L
T
E
A
E
L
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z321
862
96931
Y493
K
Q
T
S
P
P
D
Y
L
T
E
A
E
L
I
Rat
Rattus norvegicus
NP_001099331
862
96832
Y493
K
Q
T
S
P
P
D
Y
L
T
E
A
E
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006181
862
96669
Y493
M
Q
T
S
P
P
D
Y
L
T
E
A
E
L
I
Frog
Xenopus laevis
NP_001082554
858
96526
Y493
K
Q
T
C
P
P
D
Y
L
T
E
A
E
L
I
Zebra Danio
Brachydanio rerio
XP_002662012
861
96385
Y493
K
Q
T
N
P
P
D
Y
L
T
E
A
E
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96651
875
96955
Y488
S
Q
T
G
P
P
D
Y
L
T
E
S
E
L
I
Honey Bee
Apis mellifera
XP_625165
851
95935
Y491
C
Y
T
Q
P
P
D
Y
L
T
E
S
E
L
I
Nematode Worm
Caenorhab. elegans
O61660
759
85420
F438
L
T
V
G
T
E
K
F
H
A
S
G
L
R
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13099
656
74352
L336
N
C
A
R
Y
L
R
L
N
A
K
Q
S
L
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90
99.1
95.7
N.A.
95.5
94.6
N.A.
N.A.
87.4
86.1
82.3
N.A.
57.2
64.3
30.5
N.A.
Protein Similarity:
100
90.1
99.7
97.5
N.A.
97.8
97.6
N.A.
N.A.
93.9
93.2
91
N.A.
70
78.3
46.7
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
86.6
93.3
100
N.A.
80
73.3
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
93.3
93.3
100
N.A.
86.6
80
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
16
0
70
0
0
0
% A
% Cys:
8
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
85
0
0
0
0
0
0
0
8
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
85
0
85
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
16
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
93
% I
% Lys:
62
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% K
% Leu:
8
0
0
0
0
8
0
8
85
0
0
0
8
93
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
24
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
85
85
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
77
0
8
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
8
0
0
8
0
0
0
0
0
0
8
0
% R
% Ser:
8
0
0
39
0
0
0
0
0
0
8
16
8
0
0
% S
% Thr:
0
8
85
0
8
0
0
0
0
85
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
8
0
0
85
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _