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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CH25H All Species: 30.3
Human Site: Y71 Identified Species: 60.61
UniProt: O95992 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95992 NP_003947.1 272 31745 Y71 W V P A L R R Y K I H P D F S
Chimpanzee Pan troglodytes XP_507901 272 31755 Y71 W V P A L R R Y K I H P D F S
Rhesus Macaque Macaca mulatta XP_001083208 272 31831 Y71 W V P A L R R Y K I H P D F S
Dog Lupus familis XP_543596 270 30407 Y71 R V R A L R R Y K V H P D C G
Cat Felis silvestris
Mouse Mus musculus Q9Z0F5 298 34654 Y71 W V P I L R R Y K I H P D F S
Rat Rattus norvegicus Q4QQV7 298 34396 Y71 W V P I L R R Y K I H P D F S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509608 304 35019 Y105 K V P A L R R Y K L N P R A S
Chicken Gallus gallus Q5ZLL6 296 35467 Y81 F I P Y M Q K Y K I Q P D K P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5PRC0 251 29716 C71 S W T M M W S C L A L S L Y N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q20027 300 36047 A76 N V P F F K D A K I Q K D R K
Sea Urchin Strong. purpuratus XP_788589 290 34201 Y86 H W A W L R K Y K L H Q D I H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53045 309 36461 F74 F F R C L P W F I I D Q I P Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 94.8 70.5 N.A. 71.8 73.4 N.A. 56.5 24.6 N.A. 53.3 N.A. N.A. N.A. 30.3 32
Protein Similarity: 100 100 96.3 80.8 N.A. 78.5 79.8 N.A. 68.4 43.9 N.A. 67.2 N.A. N.A. N.A. 48.3 49.3
P-Site Identity: 100 100 100 66.6 N.A. 93.3 93.3 N.A. 66.6 40 N.A. 0 N.A. N.A. N.A. 33.3 40
P-Site Similarity: 100 100 100 73.3 N.A. 93.3 93.3 N.A. 80 73.3 N.A. 20 N.A. N.A. N.A. 40 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 42 0 0 0 9 0 9 0 0 0 9 0 % A
% Cys: 0 0 0 9 0 0 0 9 0 0 0 0 0 9 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 0 9 0 75 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 17 9 0 9 9 0 0 9 0 0 0 0 0 42 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % G
% His: 9 0 0 0 0 0 0 0 0 0 59 0 0 0 9 % H
% Ile: 0 9 0 17 0 0 0 0 9 67 0 0 9 9 0 % I
% Lys: 9 0 0 0 0 9 17 0 84 0 0 9 0 9 9 % K
% Leu: 0 0 0 0 75 0 0 0 9 17 9 0 9 0 0 % L
% Met: 0 0 0 9 17 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 0 0 0 0 0 0 9 0 0 0 9 % N
% Pro: 0 0 67 0 0 9 0 0 0 0 0 67 0 9 9 % P
% Gln: 0 0 0 0 0 9 0 0 0 0 17 17 0 0 0 % Q
% Arg: 9 0 17 0 0 67 59 0 0 0 0 0 9 9 0 % R
% Ser: 9 0 0 0 0 0 9 0 0 0 0 9 0 0 50 % S
% Thr: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 67 0 0 0 0 0 0 0 9 0 0 0 0 0 % V
% Trp: 42 17 0 9 0 9 9 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 9 0 0 0 75 0 0 0 0 0 9 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _