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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC2 All Species: 14.55
Human Site: S1580 Identified Species: 29.09
UniProt: O95996 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95996 NP_005874.1 2303 243949 S1580 T P P C Y S L S S S A S S L S
Chimpanzee Pan troglodytes XP_001143729 2807 307641 S1959 K E T E P P D S Q G E P S K P
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 S1582 T P P C Y S L S S S A S S L S
Dog Lupus familis XP_542202 2539 269675 S1828 T P P C Y S L S S S A S S L S
Cat Felis silvestris
Mouse Mus musculus Q9Z1K7 2274 243121 E1550 Q P R L I V D E T P P C Y S L
Rat Rattus norvegicus P70478 2842 310514 A1994 R D A E P A N A Q G Q P G K P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 T1996 K P P E P P E T Q I E S S R P
Chicken Gallus gallus
Frog Xenopus laevis P70039 2829 310863 T1987 E T E P L K Q T G T S E T Q L
Zebra Danio Brachydanio rerio XP_694133 2091 233440 E1412 Q Q D N D P E E S E K E E D M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 Q1549 A T S N P Q Q Q S S T H P S S
Honey Bee Apis mellifera XP_624558 2760 306907 P1978 Q T Q V L E N P F P D M N Q D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 S1930 S M A M R R L S S E E A P L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.2 96.4 72.6 N.A. 81.1 34.7 N.A. 35.9 N.A. 34.4 36 N.A. 24.2 22.7 N.A. 25
Protein Similarity: 100 50.4 97.3 76.1 N.A. 85.6 49.8 N.A. 49.9 N.A. 48.7 49.9 N.A. 39 38.1 N.A. 40
P-Site Identity: 100 13.3 100 100 N.A. 6.6 0 N.A. 26.6 N.A. 0 6.6 N.A. 20 0 N.A. 33.3
P-Site Similarity: 100 13.3 100 100 N.A. 13.3 13.3 N.A. 33.3 N.A. 26.6 6.6 N.A. 20 6.6 N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 17 0 0 9 0 9 0 0 25 9 0 0 0 % A
% Cys: 0 0 0 25 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 9 9 0 9 0 17 0 0 0 9 0 0 9 9 % D
% Glu: 9 9 9 25 0 9 17 17 0 17 25 17 9 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 9 17 0 0 9 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % H
% Ile: 0 0 0 0 9 0 0 0 0 9 0 0 0 0 0 % I
% Lys: 17 0 0 0 0 9 0 0 0 0 9 0 0 17 0 % K
% Leu: 0 0 0 9 17 0 34 0 0 0 0 0 0 34 17 % L
% Met: 0 9 0 9 0 0 0 0 0 0 0 9 0 0 9 % M
% Asn: 0 0 0 17 0 0 17 0 0 0 0 0 9 0 0 % N
% Pro: 0 42 34 9 34 25 0 9 0 17 9 17 17 0 25 % P
% Gln: 25 9 9 0 0 9 17 9 25 0 9 0 0 17 0 % Q
% Arg: 9 0 9 0 9 9 0 0 0 0 0 0 0 9 0 % R
% Ser: 9 0 9 0 0 25 0 42 50 34 9 34 42 17 42 % S
% Thr: 25 25 9 0 0 0 0 17 9 9 9 0 9 0 0 % T
% Val: 0 0 0 9 0 9 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 25 0 0 0 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _