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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC2 All Species: 6.06
Human Site: S1592 Identified Species: 12.12
UniProt: O95996 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95996 NP_005874.1 2303 243949 S1592 S L S E P E P S E P P A V H P
Chimpanzee Pan troglodytes XP_001143729 2807 307641 Y1971 S K P Q A S G Y A P K S F H V
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 P1594 S L S E P E P P E P P S V S P
Dog Lupus familis XP_542202 2539 269675 P1840 S L S E P D P P A H P P A R A
Cat Felis silvestris
Mouse Mus musculus Q9Z1K7 2274 243121 S1562 Y S L T S S A S S L S E P E A
Rat Rattus norvegicus P70478 2842 310514 Y2006 G K P Q A S G Y A P K S F H V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 Y2008 S R P Q A S G Y A P K S F H V
Chicken Gallus gallus
Frog Xenopus laevis P70039 2829 310863 P1999 T Q L G L R R P Q T S G Y A P
Zebra Danio Brachydanio rerio XP_694133 2091 233440 S1424 E D M E D Q Y S E G N S D D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 N1561 P S S H I L P N P I D A I A T
Honey Bee Apis mellifera XP_624558 2760 306907 Q1990 N Q D Q N N Q Q E I N T I C E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 D1942 P L S Y A V E D T P T C F S H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.2 96.4 72.6 N.A. 81.1 34.7 N.A. 35.9 N.A. 34.4 36 N.A. 24.2 22.7 N.A. 25
Protein Similarity: 100 50.4 97.3 76.1 N.A. 85.6 49.8 N.A. 49.9 N.A. 48.7 49.9 N.A. 39 38.1 N.A. 40
P-Site Identity: 100 20 80 46.6 N.A. 6.6 13.3 N.A. 20 N.A. 6.6 20 N.A. 20 6.6 N.A. 20
P-Site Similarity: 100 33.3 86.6 53.3 N.A. 6.6 26.6 N.A. 33.3 N.A. 20 33.3 N.A. 33.3 26.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 34 0 9 0 34 0 0 17 9 17 17 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 9 0 % C
% Asp: 0 9 9 0 9 9 0 9 0 0 9 0 9 9 9 % D
% Glu: 9 0 0 34 0 17 9 0 34 0 0 9 0 9 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 34 0 0 % F
% Gly: 9 0 0 9 0 0 25 0 0 9 0 9 0 0 0 % G
% His: 0 0 0 9 0 0 0 0 0 9 0 0 0 34 9 % H
% Ile: 0 0 0 0 9 0 0 0 0 17 0 0 17 0 0 % I
% Lys: 0 17 0 0 0 0 0 0 0 0 25 0 0 0 0 % K
% Leu: 0 34 17 0 9 9 0 0 0 9 0 0 0 0 0 % L
% Met: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 9 9 0 9 0 0 17 0 0 0 0 % N
% Pro: 17 0 25 0 25 0 34 25 9 50 25 9 9 0 25 % P
% Gln: 0 17 0 34 0 9 9 9 9 0 0 0 0 0 0 % Q
% Arg: 0 9 0 0 0 9 9 0 0 0 0 0 0 9 0 % R
% Ser: 42 17 42 0 9 34 0 25 9 0 17 42 0 17 0 % S
% Thr: 9 0 0 9 0 0 0 0 9 9 9 9 0 0 9 % T
% Val: 0 0 0 0 0 9 0 0 0 0 0 0 17 0 25 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 9 0 0 9 25 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _