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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC2 All Species: 15.76
Human Site: S1840 Identified Species: 31.52
UniProt: O95996 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95996 NP_005874.1 2303 243949 S1840 P S P G Q Q R S R S L H R P A
Chimpanzee Pan troglodytes XP_001143729 2807 307641 S2260 T S Q I G G T S K A P S R S G
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 S1842 P S P G Q Q R S R S L H R P G
Dog Lupus familis XP_542202 2539 269675 S2080 P S P G Q Q R S R S L H R P G
Cat Felis silvestris
Mouse Mus musculus Q9Z1K7 2274 243121 S1811 P S P E Q Q R S R S L H R P G
Rat Rattus norvegicus P70478 2842 310514 A2267 S P S E G P V A T T S P R G T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 A2268 S P N E G Q P A T T S P R G A
Chicken Gallus gallus
Frog Xenopus laevis P70039 2829 310863 V2251 P V S K K G P V F K N V P S K
Zebra Danio Brachydanio rerio XP_694133 2091 233440 N1664 S N I I R N A N I Q D Q V N S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 R1877 P A N L V A R R A L G H L A G
Honey Bee Apis mellifera XP_624558 2760 306907 N2282 A T T L R Q N N N S P N V M M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 S2268 Q K D G D A K S E T S S R R S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.2 96.4 72.6 N.A. 81.1 34.7 N.A. 35.9 N.A. 34.4 36 N.A. 24.2 22.7 N.A. 25
Protein Similarity: 100 50.4 97.3 76.1 N.A. 85.6 49.8 N.A. 49.9 N.A. 48.7 49.9 N.A. 39 38.1 N.A. 40
P-Site Identity: 100 20 93.3 93.3 N.A. 86.6 6.6 N.A. 20 N.A. 6.6 0 N.A. 20 13.3 N.A. 20
P-Site Similarity: 100 33.3 93.3 93.3 N.A. 86.6 20 N.A. 33.3 N.A. 13.3 26.6 N.A. 26.6 40 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 0 0 0 17 9 17 9 9 0 0 0 9 17 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 9 0 0 0 0 0 9 0 0 0 0 % D
% Glu: 0 0 0 25 0 0 0 0 9 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % F
% Gly: 0 0 0 34 25 17 0 0 0 0 9 0 0 17 42 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 42 0 0 0 % H
% Ile: 0 0 9 17 0 0 0 0 9 0 0 0 0 0 0 % I
% Lys: 0 9 0 9 9 0 9 0 9 9 0 0 0 0 9 % K
% Leu: 0 0 0 17 0 0 0 0 0 9 34 0 9 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 % M
% Asn: 0 9 17 0 0 9 9 17 9 0 9 9 0 9 0 % N
% Pro: 50 17 34 0 0 9 17 0 0 0 17 17 9 34 0 % P
% Gln: 9 0 9 0 34 50 0 0 0 9 0 9 0 0 0 % Q
% Arg: 0 0 0 0 17 0 42 9 34 0 0 0 67 9 0 % R
% Ser: 25 42 17 0 0 0 0 50 0 42 25 17 0 17 17 % S
% Thr: 9 9 9 0 0 0 9 0 17 25 0 0 0 0 9 % T
% Val: 0 9 0 0 9 0 9 9 0 0 0 9 17 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _