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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APC2
All Species:
32.73
Human Site:
S500
Identified Species:
65.45
UniProt:
O95996
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95996
NP_005874.1
2303
243949
S500
A
I
V
A
Q
L
A
S
D
S
E
E
L
H
Q
Chimpanzee
Pan troglodytes
XP_001143729
2807
307641
S498
A
L
V
A
Q
L
K
S
E
S
E
D
L
Q
Q
Rhesus Macaque
Macaca mulatta
XP_001095216
2303
243755
S502
A
I
V
A
Q
L
A
S
D
S
E
E
L
H
Q
Dog
Lupus familis
XP_542202
2539
269675
S788
A
I
V
A
Q
L
A
S
E
S
E
E
L
H
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1K7
2274
243121
S493
A
I
V
A
Q
L
G
S
E
S
E
E
L
H
Q
Rat
Rattus norvegicus
P70478
2842
310514
S533
A
L
V
A
Q
L
K
S
E
S
E
D
L
Q
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511806
2844
309621
S535
A
L
V
A
Q
L
K
S
E
S
E
D
L
Q
Q
Chicken
Gallus gallus
Frog
Xenopus laevis
P70039
2829
310863
S537
A
L
V
A
Q
L
K
S
E
S
E
D
L
Q
Q
Zebra Danio
Brachydanio rerio
XP_694133
2091
233440
P435
K
T
T
E
I
P
E
P
V
D
P
Q
I
C
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477152
2417
261266
N474
L
A
L
A
A
M
R
N
R
S
E
N
T
L
K
Honey Bee
Apis mellifera
XP_624558
2760
306907
S513
A
L
V
S
Q
L
K
S
P
S
D
D
L
R
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783363
3212
346162
A508
A
L
V
A
L
L
S
A
E
S
E
D
L
R
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.2
96.4
72.6
N.A.
81.1
34.7
N.A.
35.9
N.A.
34.4
36
N.A.
24.2
22.7
N.A.
25
Protein Similarity:
100
50.4
97.3
76.1
N.A.
85.6
49.8
N.A.
49.9
N.A.
48.7
49.9
N.A.
39
38.1
N.A.
40
P-Site Identity:
100
66.6
100
93.3
N.A.
86.6
66.6
N.A.
66.6
N.A.
66.6
6.6
N.A.
20
53.3
N.A.
53.3
P-Site Similarity:
100
86.6
100
100
N.A.
93.3
86.6
N.A.
86.6
N.A.
86.6
20
N.A.
46.6
80
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
84
9
0
84
9
0
25
9
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
0
0
17
9
9
50
0
0
0
% D
% Glu:
0
0
0
9
0
0
9
0
59
0
84
34
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
34
0
% H
% Ile:
0
34
0
0
9
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
9
0
0
0
0
0
42
0
0
0
0
0
0
0
9
% K
% Leu:
9
50
9
0
9
84
0
0
0
0
0
0
84
9
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
9
0
9
9
0
9
0
0
0
0
% P
% Gln:
0
0
0
0
75
0
0
0
0
0
0
9
0
34
92
% Q
% Arg:
0
0
0
0
0
0
9
0
9
0
0
0
0
17
0
% R
% Ser:
0
0
0
9
0
0
9
75
0
92
0
0
0
0
0
% S
% Thr:
0
9
9
0
0
0
0
0
0
0
0
0
9
0
0
% T
% Val:
0
0
84
0
0
0
0
0
9
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _