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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC2 All Species: 7.58
Human Site: T1390 Identified Species: 15.15
UniProt: O95996 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95996 NP_005874.1 2303 243949 T1390 A Q E D D S C T D S A E G T P
Chimpanzee Pan troglodytes XP_001143729 2807 307641 V1604 P G D D M P R V Y C V E G T P
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 T1392 A Q E D D S C T D S A E G T P
Dog Lupus familis XP_542202 2539 269675 P1642 G R R A L P V P V Y M L V P A
Cat Felis silvestris
Mouse Mus musculus Q9Z1K7 2274 243121 P1366 V Y M L V P A P A R G D D S G
Rat Rattus norvegicus P70478 2842 310514 V1639 P G D D V P R V Y C V E G T P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 V1646 P G D D M P R V Y C V E G T P
Chicken Gallus gallus
Frog Xenopus laevis P70039 2829 310863 V1643 H S D D M P R V Y C V E G T P
Zebra Danio Brachydanio rerio XP_694133 2091 233440 K1231 S G T I K N E K R F L R G V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 L1359 N G K R S S S L S S S Q P I A
Honey Bee Apis mellifera XP_624558 2760 306907 S1728 Q N Q N H T G S L E N L L N E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 S1683 E M S S D T R S T S S Q E R G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.2 96.4 72.6 N.A. 81.1 34.7 N.A. 35.9 N.A. 34.4 36 N.A. 24.2 22.7 N.A. 25
Protein Similarity: 100 50.4 97.3 76.1 N.A. 85.6 49.8 N.A. 49.9 N.A. 48.7 49.9 N.A. 39 38.1 N.A. 40
P-Site Identity: 100 33.3 100 0 N.A. 0 33.3 N.A. 33.3 N.A. 33.3 6.6 N.A. 13.3 0 N.A. 13.3
P-Site Similarity: 100 40 100 6.6 N.A. 13.3 40 N.A. 40 N.A. 40 20 N.A. 33.3 26.6 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 0 9 0 0 9 0 9 0 17 0 0 0 17 % A
% Cys: 0 0 0 0 0 0 17 0 0 34 0 0 0 0 0 % C
% Asp: 0 0 34 50 25 0 0 0 17 0 0 9 9 0 0 % D
% Glu: 9 0 17 0 0 0 9 0 0 9 0 50 9 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % F
% Gly: 9 42 0 0 0 0 9 0 0 0 9 0 59 0 17 % G
% His: 9 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 9 0 0 0 0 0 0 0 0 0 9 0 % I
% Lys: 0 0 9 0 9 0 0 9 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 9 9 0 0 9 9 0 9 17 9 0 0 % L
% Met: 0 9 9 0 25 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 9 9 0 9 0 9 0 0 0 0 9 0 0 9 0 % N
% Pro: 25 0 0 0 0 50 0 17 0 0 0 0 9 9 50 % P
% Gln: 9 17 9 0 0 0 0 0 0 0 0 17 0 0 0 % Q
% Arg: 0 9 9 9 0 0 42 0 9 9 0 9 0 9 0 % R
% Ser: 9 9 9 9 9 25 9 17 9 34 17 0 0 9 9 % S
% Thr: 0 0 9 0 0 17 0 17 9 0 0 0 0 50 0 % T
% Val: 9 0 0 0 17 0 9 34 9 0 34 0 9 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 34 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _