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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC2 All Species: 13.33
Human Site: T1814 Identified Species: 26.67
UniProt: O95996 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95996 NP_005874.1 2303 243949 T1814 G T P G P R A T P R K V A P P
Chimpanzee Pan troglodytes XP_001143729 2807 307641 P2215 S P V S K K G P P L K T P A S
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 T1816 G T P G P R A T P R K V A P P
Dog Lupus familis XP_542202 2539 269675 G2059 R A A L R K M G P P S P A Q P
Cat Felis silvestris
Mouse Mus musculus Q9Z1K7 2274 243121 T1785 G I S G P C T T P K K T G T S
Rat Rattus norvegicus P70478 2842 310514 S2239 H I P G V R N S S S S T S P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 S2240 H I P G V R N S S S S T S P V
Chicken Gallus gallus
Frog Xenopus laevis P70039 2829 310863 S2224 Q T N M P S I S R G R T M I H
Zebra Danio Brachydanio rerio XP_694133 2091 233440 G1643 H K M E R H D G Q M N R T G R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 Q1849 S C Y Q D H S Q P S S L R Q A
Honey Bee Apis mellifera XP_624558 2760 306907 K2232 K A I R G R R K A L Y S N P I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 T2205 M T A G R T T T P P R T T S P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.2 96.4 72.6 N.A. 81.1 34.7 N.A. 35.9 N.A. 34.4 36 N.A. 24.2 22.7 N.A. 25
Protein Similarity: 100 50.4 97.3 76.1 N.A. 85.6 49.8 N.A. 49.9 N.A. 48.7 49.9 N.A. 39 38.1 N.A. 40
P-Site Identity: 100 13.3 100 20 N.A. 40 26.6 N.A. 26.6 N.A. 13.3 0 N.A. 6.6 13.3 N.A. 33.3
P-Site Similarity: 100 20 100 26.6 N.A. 46.6 40 N.A. 40 N.A. 26.6 0 N.A. 20 13.3 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 17 0 0 0 17 0 9 0 0 0 25 9 9 % A
% Cys: 0 9 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 9 0 9 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 25 0 0 50 9 0 9 17 0 9 0 0 9 9 0 % G
% His: 25 0 0 0 0 17 0 0 0 0 0 0 0 0 9 % H
% Ile: 0 25 9 0 0 0 9 0 0 0 0 0 0 9 9 % I
% Lys: 9 9 0 0 9 17 0 9 0 9 34 0 0 0 0 % K
% Leu: 0 0 0 9 0 0 0 0 0 17 0 9 0 0 0 % L
% Met: 9 0 9 9 0 0 9 0 0 9 0 0 9 0 0 % M
% Asn: 0 0 9 0 0 0 17 0 0 0 9 0 9 0 0 % N
% Pro: 0 9 34 0 34 0 0 9 59 17 0 9 9 42 34 % P
% Gln: 9 0 0 9 0 0 0 9 9 0 0 0 0 17 0 % Q
% Arg: 9 0 0 9 25 42 9 0 9 17 17 9 9 0 9 % R
% Ser: 17 0 9 9 0 9 9 25 17 25 34 9 17 9 17 % S
% Thr: 0 34 0 0 0 9 17 34 0 0 0 50 17 9 0 % T
% Val: 0 0 9 0 17 0 0 0 0 0 0 17 0 0 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _