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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAK4 All Species: 13.33
Human Site: S142 Identified Species: 20.95
UniProt: O96013 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O96013 NP_001014831.1 591 64072 S142 R G R F A G H S E A G G G S G
Chimpanzee Pan troglodytes XP_525261 777 87548 S289 S S S P L D Y S F Q F T P S R
Rhesus Macaque Macaca mulatta XP_001085295 565 60953 S142 Q G R I A S H S E A G G G S G
Dog Lupus familis XP_541627 592 64165 S142 Q G R A A G R S E A G G S S G
Cat Felis silvestris
Mouse Mus musculus Q8BTW9 593 64604 S142 R A R A T G H S E A G S G S G
Rat Rattus norvegicus Q62829 544 60692 K136 K E T V N N Q K Y M S F T S G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514843 722 81837 L252 S E C S K E S L Q Y G E S E W
Chicken Gallus gallus XP_001233796 504 55780 Q102 R P R E R D P Q R P R G Q E P
Frog Xenopus laevis NP_001082100 650 73749 P186 D I P E K R G P R S H E K S D
Zebra Danio Brachydanio rerio NP_001002222 663 74742 P200 E R D R E R E P R D Y S D H V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VXE5 639 69601 P187 S S G G F K P P G A H P S L L
Honey Bee Apis mellifera XP_001122147 624 70155 N156 T N F G K Q H N Y L D K L R Q
Nematode Worm Caenorhab. elegans Q17850 572 63863 Y136 S G Q K W L Q Y D M M F I D D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q03497 939 102344 S258 K P V S V K K S F P S K N P L
Red Bread Mold Neurospora crassa Q7RZD3 954 103773 L475 V P K G P G P L P A K D I N L
Conservation
Percent
Protein Identity: 100 49.2 91.7 95 N.A. 92.7 34 N.A. 54.2 65.6 64.7 65 N.A. 50 50 32.3 N.A.
Protein Similarity: 100 59.7 92.3 96.9 N.A. 94.4 52.4 N.A. 63.4 71.2 72.6 72 N.A. 61.5 62.5 47.5 N.A.
P-Site Identity: 100 13.3 80 73.3 N.A. 73.3 13.3 N.A. 6.6 20 6.6 0 N.A. 6.6 6.6 6.6 N.A.
P-Site Similarity: 100 20 86.6 80 N.A. 73.3 20 N.A. 13.3 20 13.3 0 N.A. 6.6 13.3 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.9 28.6
Protein Similarity: N.A. N.A. N.A. N.A. 41.2 41.4
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 14 20 0 0 0 0 40 0 0 0 0 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 7 0 0 14 0 0 7 7 7 7 7 7 14 % D
% Glu: 7 14 0 14 7 7 7 0 27 0 0 14 0 14 0 % E
% Phe: 0 0 7 7 7 0 0 0 14 0 7 14 0 0 0 % F
% Gly: 0 27 7 20 0 27 7 0 7 0 34 27 20 0 34 % G
% His: 0 0 0 0 0 0 27 0 0 0 14 0 0 7 0 % H
% Ile: 0 7 0 7 0 0 0 0 0 0 0 0 14 0 0 % I
% Lys: 14 0 7 7 20 14 7 7 0 0 7 14 7 0 0 % K
% Leu: 0 0 0 0 7 7 0 14 0 7 0 0 7 7 20 % L
% Met: 0 0 0 0 0 0 0 0 0 14 7 0 0 0 0 % M
% Asn: 0 7 0 0 7 7 0 7 0 0 0 0 7 7 0 % N
% Pro: 0 20 7 7 7 0 20 20 7 14 0 7 7 7 7 % P
% Gln: 14 0 7 0 0 7 14 7 7 7 0 0 7 0 7 % Q
% Arg: 20 7 34 7 7 14 7 0 20 0 7 0 0 7 7 % R
% Ser: 27 14 7 14 0 7 7 40 0 7 14 14 20 47 0 % S
% Thr: 7 0 7 0 7 0 0 0 0 0 0 7 7 0 0 % T
% Val: 7 0 7 7 7 0 0 0 0 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 0 0 7 7 14 7 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _