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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK4
All Species:
9.09
Human Site:
S173
Identified Species:
14.29
UniProt:
O96013
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96013
NP_001014831.1
591
64072
S173
G
S
G
G
P
Q
E
S
S
R
D
K
R
P
L
Chimpanzee
Pan troglodytes
XP_525261
777
87548
D320
S
E
W
G
P
S
L
D
D
Y
D
R
R
P
K
Rhesus Macaque
Macaca mulatta
XP_001085295
565
60953
P173
G
S
G
G
P
Q
E
P
S
R
D
K
R
P
L
Dog
Lupus familis
XP_541627
592
64165
S173
G
S
G
G
P
Q
E
S
S
R
D
K
R
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTW9
593
64604
A173
G
P
G
G
P
Q
E
A
S
R
D
K
R
P
L
Rat
Rattus norvegicus
Q62829
544
60692
A167
T
A
S
E
P
P
L
A
P
P
V
S
E
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514843
722
81837
A283
N
K
T
S
P
Q
P
A
M
R
Q
R
S
R
S
Chicken
Gallus gallus
XP_001233796
504
55780
A133
P
P
E
R
D
G
P
A
E
P
R
P
G
R
P
Frog
Xenopus laevis
NP_001082100
650
73749
K217
E
R
V
V
K
R
D
K
G
E
E
K
R
P
K
Zebra Danio
Brachydanio rerio
NP_001002222
663
74742
S231
G
R
D
S
S
P
Q
S
P
R
E
K
R
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
L218
V
R
T
D
Q
T
N
L
Q
Q
Y
R
S
N
L
Honey Bee
Apis mellifera
XP_001122147
624
70155
N187
I
P
N
L
Q
N
L
N
P
N
M
Q
S
S
P
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
G167
T
S
S
L
P
Y
H
G
N
K
I
Q
D
P
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
S289
S
S
S
K
K
R
K
S
G
S
N
S
G
T
L
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
P506
L
V
P
P
A
S
L
P
A
K
D
S
G
I
G
Conservation
Percent
Protein Identity:
100
49.2
91.7
95
N.A.
92.7
34
N.A.
54.2
65.6
64.7
65
N.A.
50
50
32.3
N.A.
Protein Similarity:
100
59.7
92.3
96.9
N.A.
94.4
52.4
N.A.
63.4
71.2
72.6
72
N.A.
61.5
62.5
47.5
N.A.
P-Site Identity:
100
33.3
93.3
100
N.A.
86.6
6.6
N.A.
20
0
20
46.6
N.A.
6.6
0
20
N.A.
P-Site Similarity:
100
40
93.3
100
N.A.
93.3
20
N.A.
33.3
6.6
40
60
N.A.
20
13.3
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.9
28.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.2
41.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
0
0
27
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
7
0
7
7
7
0
40
0
7
0
0
% D
% Glu:
7
7
7
7
0
0
27
0
7
7
14
0
7
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
34
0
27
34
0
7
0
7
14
0
0
0
20
0
7
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% I
% Lys:
0
7
0
7
14
0
7
7
0
14
0
40
0
0
14
% K
% Leu:
7
0
0
14
0
0
27
7
0
0
0
0
0
0
47
% L
% Met:
0
0
0
0
0
0
0
0
7
0
7
0
0
0
0
% M
% Asn:
7
0
7
0
0
7
7
7
7
7
7
0
0
7
0
% N
% Pro:
7
20
7
7
54
14
14
14
20
14
0
7
0
54
14
% P
% Gln:
0
0
0
0
14
34
7
0
7
7
7
14
0
0
0
% Q
% Arg:
0
20
0
7
0
14
0
0
0
40
7
20
47
14
7
% R
% Ser:
14
34
20
14
7
14
0
27
27
7
0
20
20
7
7
% S
% Thr:
14
0
14
0
0
7
0
0
0
0
0
0
0
7
0
% T
% Val:
7
7
7
7
0
0
0
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
7
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _