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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK4
All Species:
20.91
Human Site:
S181
Identified Species:
32.86
UniProt:
O96013
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96013
NP_001014831.1
591
64072
S181
S
R
D
K
R
P
L
S
G
P
D
V
G
T
P
Chimpanzee
Pan troglodytes
XP_525261
777
87548
S328
D
Y
D
R
R
P
K
S
S
Y
L
N
Q
T
S
Rhesus Macaque
Macaca mulatta
XP_001085295
565
60953
S181
S
R
D
K
R
P
L
S
G
P
D
V
G
T
P
Dog
Lupus familis
XP_541627
592
64165
S181
S
R
D
K
R
P
L
S
G
P
D
V
G
T
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTW9
593
64604
S181
S
R
D
K
R
P
L
S
G
P
D
V
S
T
P
Rat
Rattus norvegicus
Q62829
544
60692
D175
P
P
V
S
E
E
E
D
E
E
E
E
E
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514843
722
81837
G291
M
R
Q
R
S
R
S
G
S
G
L
Q
E
P
I
Chicken
Gallus gallus
XP_001233796
504
55780
Q141
E
P
R
P
G
R
P
Q
E
A
A
P
N
G
P
Frog
Xenopus laevis
NP_001082100
650
73749
S225
G
E
E
K
R
P
K
S
A
Y
T
S
G
E
G
Zebra Danio
Brachydanio rerio
NP_001002222
663
74742
S239
P
R
E
K
R
P
L
S
G
P
N
I
R
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
A226
Q
Q
Y
R
S
N
L
A
P
P
S
G
G
S
M
Honey Bee
Apis mellifera
XP_001122147
624
70155
N195
P
N
M
Q
S
S
P
N
L
T
H
V
G
S
N
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
K175
N
K
I
Q
D
P
R
K
M
N
P
M
T
T
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
R297
G
S
N
S
G
T
L
R
M
K
D
V
F
T
S
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
M514
A
K
D
S
G
I
G
M
P
P
P
G
D
E
A
Conservation
Percent
Protein Identity:
100
49.2
91.7
95
N.A.
92.7
34
N.A.
54.2
65.6
64.7
65
N.A.
50
50
32.3
N.A.
Protein Similarity:
100
59.7
92.3
96.9
N.A.
94.4
52.4
N.A.
63.4
71.2
72.6
72
N.A.
61.5
62.5
47.5
N.A.
P-Site Identity:
100
33.3
100
100
N.A.
93.3
0
N.A.
6.6
6.6
33.3
66.6
N.A.
20
13.3
13.3
N.A.
P-Site Similarity:
100
40
100
100
N.A.
93.3
6.6
N.A.
13.3
6.6
40
86.6
N.A.
46.6
33.3
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.9
28.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.2
41.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
7
7
7
7
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
40
0
7
0
0
7
0
0
34
0
7
0
0
% D
% Glu:
7
7
14
0
7
7
7
0
14
7
7
7
14
20
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
14
0
0
0
20
0
7
7
34
7
0
14
40
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
7
0
0
7
0
0
0
0
0
7
0
0
7
% I
% Lys:
0
14
0
40
0
0
14
7
0
7
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
47
0
7
0
14
0
0
0
0
% L
% Met:
7
0
7
0
0
0
0
7
14
0
0
7
0
0
7
% M
% Asn:
7
7
7
0
0
7
0
7
0
7
7
7
7
0
7
% N
% Pro:
20
14
0
7
0
54
14
0
14
47
14
7
0
7
40
% P
% Gln:
7
7
7
14
0
0
0
7
0
0
0
7
7
0
0
% Q
% Arg:
0
40
7
20
47
14
7
7
0
0
0
0
7
0
0
% R
% Ser:
27
7
0
20
20
7
7
47
14
0
7
7
7
14
20
% S
% Thr:
0
0
0
0
0
7
0
0
0
7
7
0
7
54
0
% T
% Val:
0
0
7
0
0
0
0
0
0
0
0
40
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
0
0
0
0
0
0
14
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _