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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAK4 All Species: 13.94
Human Site: T277 Identified Species: 21.9
UniProt: O96013 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O96013 NP_001014831.1 591 64072 T277 Q L A P P A C T P A A P A V P
Chimpanzee Pan troglodytes XP_525261 777 87548 S463 A S Y L S S L S L S S S T Y P
Rhesus Macaque Macaca mulatta XP_001085295 565 60953 T277 Q L A P P A H T P A A P A A P
Dog Lupus familis XP_541627 592 64165 A278 P Q A R P I A A P A G P P A P
Cat Felis silvestris
Mouse Mus musculus Q8BTW9 593 64604 A276 Q L A P P A R A L A A P A V P
Rat Rattus norvegicus Q62829 544 60692 R270 D P K K K Y T R F E K I G Q G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514843 722 81837 S408 A S Y P S S P S I S S S A Y P
Chicken Gallus gallus XP_001233796 504 55780 N236 D P R T Y L D N F I K I G E G
Frog Xenopus laevis NP_001082100 650 73749 L336 P H S S D P Q L S R P V Q T Q
Zebra Danio Brachydanio rerio NP_001002222 663 74742 G342 L G P E P P H G Q P M P P P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VXE5 639 69601 S324 S S S G G A S S A A Q Q A S G
Honey Bee Apis mellifera XP_001122147 624 70155 S308 K Y S Q S A L S S G N L A V S
Nematode Worm Caenorhab. elegans Q17850 572 63863 K270 Q A R G Q K A K K K M T D A E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q03497 939 102344 T461 V M S P T L N T D S S S A N G
Red Bread Mold Neurospora crassa Q7RZD3 954 103773 T614 R Q Q P T P P T S Q H Q H P R
Conservation
Percent
Protein Identity: 100 49.2 91.7 95 N.A. 92.7 34 N.A. 54.2 65.6 64.7 65 N.A. 50 50 32.3 N.A.
Protein Similarity: 100 59.7 92.3 96.9 N.A. 94.4 52.4 N.A. 63.4 71.2 72.6 72 N.A. 61.5 62.5 47.5 N.A.
P-Site Identity: 100 6.6 86.6 40 N.A. 80 0 N.A. 20 0 0 20 N.A. 20 20 6.6 N.A.
P-Site Similarity: 100 33.3 86.6 40 N.A. 80 0 N.A. 46.6 0 6.6 20 N.A. 33.3 40 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.9 28.6
Protein Similarity: N.A. N.A. N.A. N.A. 41.2 41.4
P-Site Identity: N.A. N.A. N.A. N.A. 20 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 27 0 0 34 14 14 7 34 20 0 47 20 0 % A
% Cys: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % C
% Asp: 14 0 0 0 7 0 7 0 7 0 0 0 7 0 0 % D
% Glu: 0 0 0 7 0 0 0 0 0 7 0 0 0 7 7 % E
% Phe: 0 0 0 0 0 0 0 0 14 0 0 0 0 0 0 % F
% Gly: 0 7 0 14 7 0 0 7 0 7 7 0 14 0 27 % G
% His: 0 7 0 0 0 0 14 0 0 0 7 0 7 0 0 % H
% Ile: 0 0 0 0 0 7 0 0 7 7 0 14 0 0 0 % I
% Lys: 7 0 7 7 7 7 0 7 7 7 14 0 0 0 0 % K
% Leu: 7 20 0 7 0 14 14 7 14 0 0 7 0 0 0 % L
% Met: 0 7 0 0 0 0 0 0 0 0 14 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 7 0 0 7 0 0 7 0 % N
% Pro: 14 14 7 40 34 20 14 0 20 7 7 34 14 14 47 % P
% Gln: 27 14 7 7 7 0 7 0 7 7 7 14 7 7 7 % Q
% Arg: 7 0 14 7 0 0 7 7 0 7 0 0 0 0 7 % R
% Ser: 7 20 27 7 20 14 7 27 20 20 20 20 0 7 7 % S
% Thr: 0 0 0 7 14 0 7 27 0 0 0 7 7 7 0 % T
% Val: 7 0 0 0 0 0 0 0 0 0 0 7 0 20 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 14 0 7 7 0 0 0 0 0 0 0 14 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _