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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK4
All Species:
47.27
Human Site:
Y492
Identified Species:
74.29
UniProt:
O96013
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96013
NP_001014831.1
591
64072
Y492
E
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
Chimpanzee
Pan troglodytes
XP_525261
777
87548
Y678
E
V
I
S
R
L
P
Y
G
T
E
V
D
I
W
Rhesus Macaque
Macaca mulatta
XP_001085295
565
60953
L484
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
Dog
Lupus familis
XP_541627
592
64165
Y493
E
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTW9
593
64604
Y494
E
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
Rat
Rattus norvegicus
Q62829
544
60692
E459
A
I
E
M
V
E
G
E
P
P
Y
L
N
E
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514843
722
81837
Y623
E
V
I
S
R
L
P
Y
G
T
E
V
D
I
W
Chicken
Gallus gallus
XP_001233796
504
55780
G424
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
Frog
Xenopus laevis
NP_001082100
650
73749
Y551
E
L
I
S
R
L
P
Y
G
P
E
V
D
V
W
Zebra Danio
Brachydanio rerio
NP_001002222
663
74742
Y564
E
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
Y539
E
V
I
S
R
L
P
Y
G
P
E
V
D
I
W
Honey Bee
Apis mellifera
XP_001122147
624
70155
Y523
E
V
I
S
R
L
P
Y
G
P
E
V
D
I
W
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
Y466
E
V
V
T
R
K
Q
Y
G
P
K
V
D
V
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
Y791
E
V
V
S
R
K
E
Y
G
P
K
V
D
I
W
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
Y845
E
V
V
T
R
K
E
Y
G
R
K
V
D
I
W
Conservation
Percent
Protein Identity:
100
49.2
91.7
95
N.A.
92.7
34
N.A.
54.2
65.6
64.7
65
N.A.
50
50
32.3
N.A.
Protein Similarity:
100
59.7
92.3
96.9
N.A.
94.4
52.4
N.A.
63.4
71.2
72.6
72
N.A.
61.5
62.5
47.5
N.A.
P-Site Identity:
100
86.6
13.3
100
N.A.
100
6.6
N.A.
86.6
13.3
93.3
100
N.A.
93.3
93.3
53.3
N.A.
P-Site Similarity:
100
93.3
20
100
N.A.
100
26.6
N.A.
93.3
26.6
100
100
N.A.
100
100
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.9
28.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.2
41.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
66.6
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
86.6
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
7
0
0
0
0
0
80
0
0
% D
% Glu:
87
0
7
7
0
7
14
7
7
0
60
0
0
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
0
0
7
7
80
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
67
0
0
0
0
0
0
0
0
0
0
67
0
% I
% Lys:
0
0
0
0
0
27
0
0
0
0
20
0
0
0
0
% K
% Leu:
0
34
0
0
0
60
0
7
0
0
0
7
0
0
0
% L
% Met:
7
0
0
7
7
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
7
% N
% Pro:
0
0
7
0
0
0
60
0
7
74
7
7
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
87
0
0
0
0
7
0
0
0
0
0
% R
% Ser:
0
0
0
67
0
0
7
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
14
0
0
0
0
0
14
7
0
0
0
0
% T
% Val:
0
60
20
0
7
7
0
0
7
0
0
80
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
80
% W
% Tyr:
0
0
0
0
0
0
0
80
0
0
7
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _