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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHEK2 All Species: 25.76
Human Site: S210 Identified Species: 40.48
UniProt: O96017 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O96017 NP_001005735.1 543 60915 S210 D L T V D D Q S V Y P K A L R
Chimpanzee Pan troglodytes XP_001172779 543 60866 S210 D L T V D D Q S V Y P K A L R
Rhesus Macaque Macaca mulatta XP_001102484 543 60923 S210 D L T V D D Q S V Y P K A L R
Dog Lupus familis XP_543464 544 61233 S211 D L T V D D Q S V Y P K E L R
Cat Felis silvestris
Mouse Mus musculus Q9Z265 546 61070 S214 D L T V D D Q S V Y P K E L R
Rat Rattus norvegicus NP_446129 545 60912 S213 D L T V D D Q S V Y P K E L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508699 537 60493 T203 E K Y I M Y K T L G S G A C G
Chicken Gallus gallus NP_001073576 522 58779 A207 S K T L G S G A C G E V K L A
Frog Xenopus laevis NP_001082016 517 58243 G201 M S R P I G S G A C G E V K L
Zebra Danio Brachydanio rerio Q501V0 422 47914 E128 P Y A I K M I E T R Y R E G R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61267 476 54243 G183 V N R K L G S G A Y G L V R L
Honey Bee Apis mellifera XP_624334 480 54300 G186 K M I F N K V G C K K F A L K
Nematode Worm Caenorhab. elegans Q9U1Y5 476 53320 K183 L G K G G F G K V L L G Y K K
Sea Urchin Strong. purpuratus XP_794585 480 52849 L186 G A C G Q V K L A F E K G T C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39009 513 58614 Y200 P V S F F D K Y L L G K E L G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99 89.3 N.A. 83.1 83.4 N.A. 74.4 67.5 59.6 28.1 N.A. 34 37.2 30.2 43.2
Protein Similarity: 100 99.8 99 93 N.A. 89.7 89.9 N.A. 82.1 77.9 73.1 41.9 N.A. 51.5 54.5 49.5 58.3
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 6.6 13.3 0 6.6 N.A. 6.6 13.3 6.6 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 40 26.6 6.6 20 N.A. 6.6 33.3 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 0 0 0 7 20 0 0 0 34 0 7 % A
% Cys: 0 0 7 0 0 0 0 0 14 7 0 0 0 7 7 % C
% Asp: 40 0 0 0 40 47 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 0 0 0 0 0 7 0 0 14 7 34 0 0 % E
% Phe: 0 0 0 14 7 7 0 0 0 7 0 7 0 0 0 % F
% Gly: 7 7 0 14 14 14 14 20 0 14 20 14 7 7 14 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 14 7 0 7 0 0 0 0 0 0 0 0 % I
% Lys: 7 14 7 7 7 7 20 7 0 7 7 54 7 14 14 % K
% Leu: 7 40 0 7 7 0 0 7 14 14 7 7 0 60 14 % L
% Met: 7 7 0 0 7 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 14 0 0 7 0 0 0 0 0 0 40 0 0 0 0 % P
% Gln: 0 0 0 0 7 0 40 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 14 0 0 0 0 0 0 7 0 7 0 7 47 % R
% Ser: 7 7 7 0 0 7 14 40 0 0 7 0 0 0 0 % S
% Thr: 0 0 47 0 0 0 0 7 7 0 0 0 0 7 0 % T
% Val: 7 7 0 40 0 7 7 0 47 0 0 7 14 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 7 0 0 7 0 7 0 47 7 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _