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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHEK2 All Species: 23.33
Human Site: S223 Identified Species: 36.67
UniProt: O96017 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O96017 NP_001005735.1 543 60915 S223 L R D E Y I M S K T L G S G A
Chimpanzee Pan troglodytes XP_001172779 543 60866 S223 L R D E Y I M S K T L G S G A
Rhesus Macaque Macaca mulatta XP_001102484 543 60923 S223 L R D E Y I M S K T L G S G A
Dog Lupus familis XP_543464 544 61233 S224 L R D E Y I M S K T L G S G A
Cat Felis silvestris
Mouse Mus musculus Q9Z265 546 61070 S227 L R D E Y I M S K T L G S G A
Rat Rattus norvegicus NP_446129 545 60912 S226 L R D E Y I M S K T L G S G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508699 537 60493 F216 C G E V K L A F E K T T C K K
Chicken Gallus gallus NP_001073576 522 58779 C220 L A F E K S T C N K V A V K I
Frog Xenopus laevis NP_001082016 517 58243 V214 K L A F Q K S V C K K V A V K
Zebra Danio Brachydanio rerio Q501V0 422 47914 E141 G R E V C E S E L C V L R R V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61267 476 54243 T196 R L V Y D T R T C Q Q F A M K
Honey Bee Apis mellifera XP_624334 480 54300 G199 L K T I M K L G G T T N G Q K
Nematode Worm Caenorhab. elegans Q9U1Y5 476 53320 V196 K K S D R S V V A I K Q L N T
Sea Urchin Strong. purpuratus XP_794585 480 52849 K199 T C R K V A V K I I E K K T F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39009 513 58614 L213 L G A G H Y A L V K E A K N K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99 89.3 N.A. 83.1 83.4 N.A. 74.4 67.5 59.6 28.1 N.A. 34 37.2 30.2 43.2
Protein Similarity: 100 99.8 99 93 N.A. 89.7 89.9 N.A. 82.1 77.9 73.1 41.9 N.A. 51.5 54.5 49.5 58.3
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 13.3 0 6.6 N.A. 0 13.3 0 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 20 20 6.6 20 N.A. 13.3 26.6 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 14 0 0 7 14 0 7 0 0 14 14 0 40 % A
% Cys: 7 7 0 0 7 0 0 7 14 7 0 0 7 0 0 % C
% Asp: 0 0 40 7 7 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 14 47 0 7 0 7 7 0 14 0 0 0 0 % E
% Phe: 0 0 7 7 0 0 0 7 0 0 0 7 0 0 7 % F
% Gly: 7 14 0 7 0 0 0 7 7 0 0 40 7 40 0 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 0 40 0 0 7 14 0 0 0 0 7 % I
% Lys: 14 14 0 7 14 14 0 7 40 27 14 7 14 14 34 % K
% Leu: 60 14 0 0 0 7 7 7 7 0 40 7 7 0 0 % L
% Met: 0 0 0 0 7 0 40 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 0 0 0 0 0 0 7 0 0 7 0 14 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 7 0 0 0 0 7 7 7 0 7 0 % Q
% Arg: 7 47 7 0 7 0 7 0 0 0 0 0 7 7 0 % R
% Ser: 0 0 7 0 0 14 14 40 0 0 0 0 40 0 0 % S
% Thr: 7 0 7 0 0 7 7 7 0 47 14 7 0 7 7 % T
% Val: 0 0 7 14 7 0 14 14 7 0 14 7 7 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 40 7 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _