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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHEK2 All Species: 27.58
Human Site: S456 Identified Species: 43.33
UniProt: O96017 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O96017 NP_001005735.1 543 60915 S456 P E V W A E V S E K A L D L V
Chimpanzee Pan troglodytes XP_001172779 543 60866 S456 P E V W A E V S E K A L D L V
Rhesus Macaque Macaca mulatta XP_001102484 543 60923 S456 P E V W A E V S E K A L D L V
Dog Lupus familis XP_543464 544 61233 S457 P E V W A E V S E K A L D L V
Cat Felis silvestris
Mouse Mus musculus Q9Z265 546 61070 S460 P E V W T D V S E E A L D L V
Rat Rattus norvegicus NP_446129 545 60912 S459 P E V W T D V S E K A L D L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508699 537 60493 A434 T L N F I P K A W A H V S E M
Chicken Gallus gallus NP_001073576 522 58779 S433 S K E W K H V S N M A L D L V
Frog Xenopus laevis NP_001082016 517 58243 S428 A A A W R N V S E Q A F D L V
Zebra Danio Brachydanio rerio Q501V0 422 47914 H350 S A G Q A L K H P W I V S M A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61267 476 54243 P405 G R F A Y G H P S W K S V S Q
Honey Bee Apis mellifera XP_624334 480 54300 I409 T S K A I D L I K R M M T V N
Nematode Worm Caenorhab. elegans Q9U1Y5 476 53320 I405 F H A Q W R R I T V E T Q N M
Sea Urchin Strong. purpuratus XP_794585 480 52849 A408 K Y W G S V S A P G F D V V P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39009 513 58614 A437 L K E Q I L Q A K Y A F Y S P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99 89.3 N.A. 83.1 83.4 N.A. 74.4 67.5 59.6 28.1 N.A. 34 37.2 30.2 43.2
Protein Similarity: 100 99.8 99 93 N.A. 89.7 89.9 N.A. 82.1 77.9 73.1 41.9 N.A. 51.5 54.5 49.5 58.3
P-Site Identity: 100 100 100 100 N.A. 80 86.6 N.A. 0 53.3 53.3 6.6 N.A. 0 0 0 0
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 26.6 60 60 20 N.A. 0 40 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 14 14 14 34 0 0 20 0 7 60 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 20 0 0 0 0 0 7 54 0 0 % D
% Glu: 0 40 14 0 0 27 0 0 47 7 7 0 0 7 0 % E
% Phe: 7 0 7 7 0 0 0 0 0 0 7 14 0 0 0 % F
% Gly: 7 0 7 7 0 7 0 0 0 7 0 0 0 0 0 % G
% His: 0 7 0 0 0 7 7 7 0 0 7 0 0 0 0 % H
% Ile: 0 0 0 0 20 0 0 14 0 0 7 0 0 0 0 % I
% Lys: 7 14 7 0 7 0 14 0 14 34 7 0 0 0 0 % K
% Leu: 7 7 0 0 0 14 7 0 0 0 0 47 0 54 0 % L
% Met: 0 0 0 0 0 0 0 0 0 7 7 7 0 7 14 % M
% Asn: 0 0 7 0 0 7 0 0 7 0 0 0 0 7 7 % N
% Pro: 40 0 0 0 0 7 0 7 14 0 0 0 0 0 14 % P
% Gln: 0 0 0 20 0 0 7 0 0 7 0 0 7 0 7 % Q
% Arg: 0 7 0 0 7 7 7 0 0 7 0 0 0 0 0 % R
% Ser: 14 7 0 0 7 0 7 54 7 0 0 7 14 14 0 % S
% Thr: 14 0 0 0 14 0 0 0 7 0 0 7 7 0 0 % T
% Val: 0 0 40 0 0 7 54 0 0 7 0 14 14 14 54 % V
% Trp: 0 0 7 54 7 0 0 0 7 14 0 0 0 0 0 % W
% Tyr: 0 7 0 0 7 0 0 0 0 7 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _