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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
23.03
Human Site:
S516
Identified Species:
36.19
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
S516
P
Q
V
L
A
Q
P
S
T
S
R
K
R
P
R
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
S516
P
Q
V
L
A
Q
P
S
T
S
R
K
R
P
R
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
S516
P
Q
V
L
A
Q
P
S
T
S
R
K
R
P
H
Dog
Lupus familis
XP_543464
544
61233
S517
L
Q
V
P
A
Q
P
S
T
S
R
K
R
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
T519
L
P
V
A
P
A
Q
T
S
S
Q
K
R
P
L
Rat
Rattus norvegicus
NP_446129
545
60912
T518
L
P
L
A
P
A
Q
T
S
G
Q
K
R
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
S499
P
Q
H
P
I
Q
P
S
T
S
R
K
R
A
W
Chicken
Gallus gallus
NP_001073576
522
58779
V493
P
Q
T
S
K
M
P
V
A
T
R
K
R
L
H
Frog
Xenopus laevis
NP_001082016
517
58243
I487
P
P
I
K
K
N
I
I
R
K
R
G
H
E
W
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
S398
R
S
S
R
S
T
K
S
S
K
A
R
R
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
R452
P
M
L
Q
K
A
K
R
L
M
K
L
D
G
M
Honey Bee
Apis mellifera
XP_624334
480
54300
E456
N
D
E
N
I
P
P
E
S
I
T
S
N
I
Q
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
I452
K
Q
D
I
L
K
S
I
K
P
I
S
A
A
A
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
G455
R
S
D
D
S
G
D
G
A
F
D
K
T
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
S487
F
N
D
I
Q
Q
Q
S
S
V
S
L
E
L
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
93.3
73.3
N.A.
33.3
20
N.A.
66.6
40
13.3
20
N.A.
6.6
6.6
6.6
6.6
P-Site Similarity:
100
100
93.3
73.3
N.A.
53.3
46.6
N.A.
66.6
46.6
20
40
N.A.
20
20
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
14
27
20
0
0
14
0
7
0
7
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
20
7
0
0
7
0
0
0
7
0
7
0
7
% D
% Glu:
0
0
7
0
0
0
0
7
0
0
0
0
7
14
0
% E
% Phe:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
7
0
7
0
7
0
7
0
7
0
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
0
7
0
14
% H
% Ile:
0
0
7
14
14
0
7
14
0
7
7
0
0
7
0
% I
% Lys:
7
0
0
7
20
7
14
0
7
14
7
60
0
0
0
% K
% Leu:
20
0
14
20
7
0
0
0
7
0
0
14
0
27
20
% L
% Met:
0
7
0
0
0
7
0
0
0
7
0
0
0
0
7
% M
% Asn:
7
7
0
7
0
7
0
0
0
0
0
0
7
0
0
% N
% Pro:
47
20
0
14
14
7
47
0
0
7
0
0
0
34
0
% P
% Gln:
0
47
0
7
7
40
20
0
0
0
14
0
0
0
14
% Q
% Arg:
14
0
0
7
0
0
0
7
7
0
47
7
60
0
20
% R
% Ser:
0
14
7
7
14
0
7
47
34
40
7
14
0
0
0
% S
% Thr:
0
0
7
0
0
7
0
14
34
7
7
0
7
0
0
% T
% Val:
0
0
34
0
0
0
0
7
0
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
14
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _