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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHEK2 All Species: 25.15
Human Site: T517 Identified Species: 39.52
UniProt: O96017 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O96017 NP_001005735.1 543 60915 T517 Q V L A Q P S T S R K R P R E
Chimpanzee Pan troglodytes XP_001172779 543 60866 T517 Q V L A Q P S T S R K R P R E
Rhesus Macaque Macaca mulatta XP_001102484 543 60923 T517 Q V L A Q P S T S R K R P H E
Dog Lupus familis XP_543464 544 61233 T518 Q V P A Q P S T S R K R L L E
Cat Felis silvestris
Mouse Mus musculus Q9Z265 546 61070 S520 P V A P A Q T S S Q K R P L E
Rat Rattus norvegicus NP_446129 545 60912 S519 P L A P A Q T S G Q K R P L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508699 537 60493 T500 Q H P I Q P S T S R K R A W E
Chicken Gallus gallus NP_001073576 522 58779 A494 Q T S K M P V A T R K R L H E
Frog Xenopus laevis NP_001082016 517 58243 R488 P I K K N I I R K R G H E W D
Zebra Danio Brachydanio rerio Q501V0 422 47914 S399 S S R S T K S S K A R R L R E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61267 476 54243 L453 M L Q K A K R L M K L D G M E
Honey Bee Apis mellifera XP_624334 480 54300 S457 D E N I P P E S I T S N I Q C
Nematode Worm Caenorhab. elegans Q9U1Y5 476 53320 K453 Q D I L K S I K P I S A A A P
Sea Urchin Strong. purpuratus XP_794585 480 52849 A456 S D D S G D G A F D K T E D V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39009 513 58614 S488 N D I Q Q Q S S V S L E L Q R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99 89.3 N.A. 83.1 83.4 N.A. 74.4 67.5 59.6 28.1 N.A. 34 37.2 30.2 43.2
Protein Similarity: 100 99.8 99 93 N.A. 89.7 89.9 N.A. 82.1 77.9 73.1 41.9 N.A. 51.5 54.5 49.5 58.3
P-Site Identity: 100 100 93.3 80 N.A. 40 26.6 N.A. 66.6 40 6.6 26.6 N.A. 6.6 6.6 6.6 6.6
P-Site Similarity: 100 100 93.3 80 N.A. 60 53.3 N.A. 66.6 46.6 20 46.6 N.A. 20 20 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 14 27 20 0 0 14 0 7 0 7 14 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 7 20 7 0 0 7 0 0 0 7 0 7 0 7 7 % D
% Glu: 0 7 0 0 0 0 7 0 0 0 0 7 14 0 67 % E
% Phe: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 7 0 7 0 7 0 7 0 7 0 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 7 0 14 0 % H
% Ile: 0 7 14 14 0 7 14 0 7 7 0 0 7 0 0 % I
% Lys: 0 0 7 20 7 14 0 7 14 7 60 0 0 0 0 % K
% Leu: 0 14 20 7 0 0 0 7 0 0 14 0 27 20 0 % L
% Met: 7 0 0 0 7 0 0 0 7 0 0 0 0 7 0 % M
% Asn: 7 0 7 0 7 0 0 0 0 0 0 7 0 0 0 % N
% Pro: 20 0 14 14 7 47 0 0 7 0 0 0 34 0 7 % P
% Gln: 47 0 7 7 40 20 0 0 0 14 0 0 0 14 0 % Q
% Arg: 0 0 7 0 0 0 7 7 0 47 7 60 0 20 7 % R
% Ser: 14 7 7 14 0 7 47 34 40 7 14 0 0 0 0 % S
% Thr: 0 7 0 0 7 0 14 34 7 7 0 7 0 0 0 % T
% Val: 0 34 0 0 0 0 7 0 7 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 14 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _