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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHEK2 All Species: 28.18
Human Site: Y136 Identified Species: 44.29
UniProt: O96017 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O96017 NP_001005735.1 543 60915 Y136 L L K R T D K Y R T Y S K K H
Chimpanzee Pan troglodytes XP_001172779 543 60866 Y136 L L K R T D K Y R T Y S K K H
Rhesus Macaque Macaca mulatta XP_001102484 543 60923 Y136 L L K R T D K Y R T Y S K K H
Dog Lupus familis XP_543464 544 61233 Y137 L L K R T D K Y R T Y S K K H
Cat Felis silvestris
Mouse Mus musculus Q9Z265 546 61070 Y140 L L R R T D K Y R T Y S K K H
Rat Rattus norvegicus NP_446129 545 60912 Y139 L L K R T D K Y R T Y S K K H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508699 537 60493 G129 F R I F R E L G P K S S Y I T
Chicken Gallus gallus NP_001073576 522 58779 Y133 E M G P K N S Y V A Y I E D H
Frog Xenopus laevis NP_001082016 517 58243 S127 Q E L G H G H S R V A N I E D
Zebra Danio Brachydanio rerio Q501V0 422 47914 S54 S P S P Q G Q S Q A V A K V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61267 476 54243 T109 K R A N C E L T N P V Y I Q D
Honey Bee Apis mellifera XP_624334 480 54300 T112 E D L S Q N G T F V N G K K V
Nematode Worm Caenorhab. elegans Q9U1Y5 476 53320 R109 D R D T E T R R I Y L H D H S
Sea Urchin Strong. purpuratus XP_794585 480 52849 L112 K N P C Y Q T L S K T H F R I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39009 513 58614 V126 L K N G D R I V F G K S C S F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99 89.3 N.A. 83.1 83.4 N.A. 74.4 67.5 59.6 28.1 N.A. 34 37.2 30.2 43.2
Protein Similarity: 100 99.8 99 93 N.A. 89.7 89.9 N.A. 82.1 77.9 73.1 41.9 N.A. 51.5 54.5 49.5 58.3
P-Site Identity: 100 100 100 100 N.A. 93.3 100 N.A. 6.6 20 6.6 6.6 N.A. 0 13.3 0 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 40 20 26.6 N.A. 13.3 20 6.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 0 0 0 0 14 7 7 0 0 0 % A
% Cys: 0 0 0 7 7 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 7 7 7 0 7 40 0 0 0 0 0 0 7 7 14 % D
% Glu: 14 7 0 0 7 14 0 0 0 0 0 0 7 7 0 % E
% Phe: 7 0 0 7 0 0 0 0 14 0 0 0 7 0 7 % F
% Gly: 0 0 7 14 0 14 7 7 0 7 0 7 0 0 0 % G
% His: 0 0 0 0 7 0 7 0 0 0 0 14 0 7 47 % H
% Ile: 0 0 7 0 0 0 7 0 7 0 0 7 14 7 7 % I
% Lys: 14 7 34 0 7 0 40 0 0 14 7 0 54 47 0 % K
% Leu: 47 40 14 0 0 0 14 7 0 0 7 0 0 0 0 % L
% Met: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 7 7 0 14 0 0 7 0 7 7 0 0 0 % N
% Pro: 0 7 7 14 0 0 0 0 7 7 0 0 0 0 0 % P
% Gln: 7 0 0 0 14 7 7 0 7 0 0 0 0 7 0 % Q
% Arg: 0 20 7 40 7 7 7 7 47 0 0 0 0 7 0 % R
% Ser: 7 0 7 7 0 0 7 14 7 0 7 54 0 7 14 % S
% Thr: 0 0 0 7 40 7 7 14 0 40 7 0 0 0 7 % T
% Val: 0 0 0 0 0 0 0 7 7 14 14 0 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 47 0 7 47 7 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _