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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ACTL6A All Species: 26.97
Human Site: S318 Identified Species: 49.44
UniProt: O96019 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O96019 NP_004292.1 429 47461 S318 P S N V K G L S G N T M L G V
Chimpanzee Pan troglodytes XP_001140943 374 41374 G269 L S G N T M L G V G H V V T T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848224 453 50289 S342 P S N V K G L S G N T M L G V
Cat Felis silvestris
Mouse Mus musculus Q9Z2N8 429 47429 S318 P S N V K G L S G N T M L G V
Rat Rattus norvegicus NP_001034122 429 47402 S318 P S N V K G L S G N T M L G V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521333 303 33827 G198 L S G N T M L G V S H V V T T
Chicken Gallus gallus XP_422784 720 79965 S609 P S N V K G L S G N T M L G V
Frog Xenopus laevis NP_001080451 429 47605 S318 P S N V K G L S G N T M L G V
Zebra Danio Brachydanio rerio NP_775347 429 47223 S318 P S N A K G L S G N T M L G V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611209 425 47301 G320 L F D N A M L G A G Q L A S T
Honey Bee Apis mellifera XP_625202 440 49061 V329 V Q M R G G M V G N T M L G V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P53472 376 41830 E271 Q P A F L G M E S A G I H E T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M92 441 48918 M330 G M E K Y A E M I P S V R G L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.8 N.A. 92.9 N.A. 98.8 98.5 N.A. 70.1 59 92.3 88.3 N.A. 55.9 60.6 N.A. 34.9
Protein Similarity: 100 83.4 N.A. 93.5 N.A. 100 100 N.A. 70.6 59.5 96.5 94.8 N.A. 73.4 77 N.A. 55.7
P-Site Identity: 100 13.3 N.A. 100 N.A. 100 100 N.A. 13.3 100 100 93.3 N.A. 6.6 53.3 N.A. 6.6
P-Site Similarity: 100 26.6 N.A. 100 N.A. 100 100 N.A. 33.3 100 100 93.3 N.A. 20 60 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 43.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 63.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 8 8 0 0 8 8 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 8 8 0 0 0 0 0 8 0 % E
% Phe: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 16 0 8 70 0 24 62 16 8 0 0 70 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 16 0 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 8 0 0 0 % I
% Lys: 0 0 0 8 54 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 24 0 0 0 8 0 77 0 0 0 0 8 62 0 8 % L
% Met: 0 8 8 0 0 24 16 8 0 0 0 62 0 0 0 % M
% Asn: 0 0 54 24 0 0 0 0 0 62 0 0 0 0 0 % N
% Pro: 54 8 0 0 0 0 0 0 0 8 0 0 0 0 0 % P
% Gln: 8 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 0 % R
% Ser: 0 70 0 0 0 0 0 54 8 8 8 0 0 8 0 % S
% Thr: 0 0 0 0 16 0 0 0 0 0 62 0 0 16 31 % T
% Val: 8 0 0 47 0 0 0 8 16 0 0 24 16 0 62 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _