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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DHFR
All Species:
38.48
Human Site:
S43
Identified Species:
65.13
UniProt:
P00374
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P00374
NP_000782.1
187
21453
S43
Q
R
M
T
T
T
S
S
V
E
G
K
Q
N
L
Chimpanzee
Pan troglodytes
XP_001134992
187
21407
S43
Q
R
M
T
T
T
S
S
V
E
G
K
Q
N
L
Rhesus Macaque
Macaca mulatta
XP_001110551
187
21428
S43
Q
R
M
T
T
T
S
S
V
E
G
K
Q
N
L
Dog
Lupus familis
XP_851329
191
21936
S47
Q
R
M
T
T
N
S
S
V
E
G
K
Q
N
L
Cat
Felis silvestris
Mouse
Mus musculus
P00375
187
21588
S43
Q
R
M
T
T
T
S
S
V
E
G
K
Q
N
L
Rat
Rattus norvegicus
Q920D2
187
21620
S43
Q
R
M
T
T
T
S
S
V
E
G
K
Q
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512236
463
51638
T54
Q
K
M
T
T
T
P
T
V
K
G
K
Q
N
L
Chicken
Gallus gallus
P00378
189
21631
H42
Q
R
M
T
S
T
S
H
V
E
G
K
Q
N
A
Frog
Xenopus laevis
NP_001088506
189
21877
T45
Q
R
L
T
M
T
P
T
V
E
G
K
K
N
V
Zebra Danio
Brachydanio rerio
NP_571850
190
21680
S45
Q
K
M
T
M
T
P
S
D
E
G
K
K
N
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P17719
182
20756
S41
S
R
T
T
K
R
T
S
D
P
T
K
Q
N
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q93341
189
21583
S41
A
S
V
T
K
N
V
S
D
Q
S
K
R
N
A
Sea Urchin
Strong. purpuratus
XP_780421
189
21372
Q46
E
R
L
T
K
T
A
Q
M
E
G
M
K
N
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07807
211
24242
K46
R
Q
V
T
S
L
T
K
D
P
N
K
K
N
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.8
87.9
N.A.
89.8
89.8
N.A.
29.8
73.5
62.9
59.4
N.A.
44.3
N.A.
35.4
54.5
Protein Similarity:
100
100
98.9
93.7
N.A.
96.2
96.2
N.A.
34.5
86.2
80.9
74.2
N.A.
64.7
N.A.
57.6
71.4
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
73.3
80
60
60
N.A.
40
N.A.
26.6
40
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
93.3
86.6
86.6
80
N.A.
46.6
N.A.
46.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
36
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
29
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
72
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
79
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
15
0
0
22
0
0
8
0
8
0
93
29
0
0
% K
% Leu:
0
0
15
0
0
8
0
0
0
0
0
0
0
0
50
% L
% Met:
0
0
65
0
15
0
0
0
8
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
15
0
0
0
0
8
0
0
100
0
% N
% Pro:
0
0
0
0
0
0
22
0
0
15
0
0
0
0
0
% P
% Gln:
72
8
0
0
0
0
0
8
0
8
0
0
65
0
0
% Q
% Arg:
8
72
0
0
0
8
0
0
0
0
0
0
8
0
0
% R
% Ser:
8
8
0
0
15
0
50
65
0
0
8
0
0
0
0
% S
% Thr:
0
0
8
100
50
72
15
15
0
0
8
0
0
0
0
% T
% Val:
0
0
15
0
0
0
8
0
65
0
0
0
0
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _