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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHFR All Species: 13.64
Human Site: T101 Identified Species: 23.08
UniProt: P00374 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00374 NP_000782.1 187 21453 T101 L D D A L K L T E Q P E L A N
Chimpanzee Pan troglodytes XP_001134992 187 21407 T101 L D D A L K L T E Q P E L A S
Rhesus Macaque Macaca mulatta XP_001110551 187 21428 T101 L D D A L K L T E Q P E L A N
Dog Lupus familis XP_851329 191 21936 T105 L D D A L K L T E Q P E L A N
Cat Felis silvestris
Mouse Mus musculus P00375 187 21588 I101 L D D A L R L I E Q P E L A S
Rat Rattus norvegicus Q920D2 187 21620 I101 L D D A L K L I E Q P E L A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512236 463 51638 L112 L D D A L N L L H L P E L A S
Chicken Gallus gallus P00378 189 21631 L100 L D D A L A L L D S P E L K S
Frog Xenopus laevis NP_001088506 189 21877 L103 L T E A I D L L E D P E L K D
Zebra Danio Brachydanio rerio NP_571850 190 21680 L103 F S S A L H L L D S G E L E K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P17719 182 20756 I99 N L E T A M K I L E E Q N E V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q93341 189 21583 L99 L E A A M K L L S E P P F V D
Sea Urchin Strong. purpuratus XP_780421 189 21372 F104 L N E A V K L F S S P P L S E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07807 211 24242 A104 Q S N S L A N A I M N L E S N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 97.8 87.9 N.A. 89.8 89.8 N.A. 29.8 73.5 62.9 59.4 N.A. 44.3 N.A. 35.4 54.5
Protein Similarity: 100 100 98.9 93.7 N.A. 96.2 96.2 N.A. 34.5 86.2 80.9 74.2 N.A. 64.7 N.A. 57.6 71.4
P-Site Identity: 100 93.3 100 100 N.A. 80 86.6 N.A. 66.6 60 46.6 33.3 N.A. 0 N.A. 33.3 40
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 73.3 73.3 66.6 40 N.A. 20 N.A. 60 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 31.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 86 8 15 0 8 0 0 0 0 0 50 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 58 58 0 0 8 0 0 15 8 0 0 0 0 15 % D
% Glu: 0 8 22 0 0 0 0 0 50 15 8 72 8 15 8 % E
% Phe: 8 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 22 8 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 50 8 0 0 0 0 0 0 15 8 % K
% Leu: 79 8 0 0 72 0 86 36 8 8 0 8 79 0 0 % L
% Met: 0 0 0 0 8 8 0 0 0 8 0 0 0 0 0 % M
% Asn: 8 8 8 0 0 8 8 0 0 0 8 0 8 0 29 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 79 15 0 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 43 0 8 0 0 0 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 15 8 8 0 0 0 0 15 22 0 0 0 15 36 % S
% Thr: 0 8 0 8 0 0 0 29 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _