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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DHFR
All Species:
30.91
Human Site:
Y157
Identified Species:
52.31
UniProt:
P00374
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P00374
NP_000782.1
187
21453
Y157
P
E
I
D
L
E
K
Y
K
L
L
P
E
Y
P
Chimpanzee
Pan troglodytes
XP_001134992
187
21407
Y157
P
E
I
D
L
E
K
Y
K
L
L
P
E
Y
P
Rhesus Macaque
Macaca mulatta
XP_001110551
187
21428
Y157
P
E
I
D
L
E
K
Y
K
L
L
P
E
Y
P
Dog
Lupus familis
XP_851329
191
21936
Y161
P
E
I
D
L
E
K
Y
K
L
L
P
E
Y
P
Cat
Felis silvestris
Mouse
Mus musculus
P00375
187
21588
Y157
P
E
I
D
L
G
K
Y
K
L
L
P
E
Y
P
Rat
Rattus norvegicus
Q920D2
187
21620
Y157
P
E
I
D
L
E
K
Y
K
L
L
P
E
Y
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512236
463
51638
Y168
P
E
I
D
L
E
K
Y
K
L
I
P
E
Y
P
Chicken
Gallus gallus
P00378
189
21631
F156
P
E
I
D
Y
K
D
F
K
L
L
T
E
Y
P
Frog
Xenopus laevis
NP_001088506
189
21877
F159
P
E
I
N
L
N
S
F
Q
L
L
P
Q
Y
P
Zebra Danio
Brachydanio rerio
NP_571850
190
21680
Y159
P
N
F
D
M
D
K
Y
K
L
L
P
E
F
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P17719
182
20756
R153
P
A
I
P
D
S
F
R
E
V
A
P
D
S
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q93341
189
21583
M155
K
S
L
D
F
S
K
M
E
K
V
Q
N
A
E
Sea Urchin
Strong. purpuratus
XP_780421
189
21372
F160
P
E
F
D
L
D
R
F
K
L
V
T
D
P
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07807
211
24242
L175
S
E
Q
D
P
A
Q
L
K
E
F
L
P
P
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.8
87.9
N.A.
89.8
89.8
N.A.
29.8
73.5
62.9
59.4
N.A.
44.3
N.A.
35.4
54.5
Protein Similarity:
100
100
98.9
93.7
N.A.
96.2
96.2
N.A.
34.5
86.2
80.9
74.2
N.A.
64.7
N.A.
57.6
71.4
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
93.3
66.6
60
66.6
N.A.
20
N.A.
13.3
40
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
100
80
86.6
86.6
N.A.
40
N.A.
33.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
0
0
0
8
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
86
8
15
8
0
0
0
0
0
15
0
8
% D
% Glu:
0
79
0
0
0
43
0
0
15
8
0
0
65
0
8
% E
% Phe:
0
0
15
0
8
0
8
22
0
0
8
0
0
8
0
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
72
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
8
0
0
0
0
8
65
0
79
8
0
0
0
0
8
% K
% Leu:
0
0
8
0
65
0
0
8
0
79
65
8
0
0
0
% L
% Met:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
8
0
8
0
0
0
0
0
0
8
0
0
% N
% Pro:
86
0
0
8
8
0
0
0
0
0
0
72
8
15
72
% P
% Gln:
0
0
8
0
0
0
8
0
8
0
0
8
8
0
0
% Q
% Arg:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% R
% Ser:
8
8
0
0
0
15
8
0
0
0
0
0
0
8
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
8
15
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
58
0
0
0
0
0
65
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _