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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DHFR
All Species:
38.18
Human Site:
Y34
Identified Species:
64.62
UniProt:
P00374
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P00374
NP_000782.1
187
21453
Y34
P
L
R
N
E
F
R
Y
F
Q
R
M
T
T
T
Chimpanzee
Pan troglodytes
XP_001134992
187
21407
Y34
P
L
R
N
E
F
R
Y
F
Q
R
M
T
T
T
Rhesus Macaque
Macaca mulatta
XP_001110551
187
21428
Y34
P
L
R
N
E
F
R
Y
F
Q
R
M
T
T
T
Dog
Lupus familis
XP_851329
191
21936
C38
P
L
R
N
E
F
K
C
F
Q
R
M
T
T
N
Cat
Felis silvestris
Mouse
Mus musculus
P00375
187
21588
Y34
P
L
R
N
E
F
K
Y
F
Q
R
M
T
T
T
Rat
Rattus norvegicus
Q920D2
187
21620
Y34
L
L
R
N
E
F
K
Y
F
Q
R
M
T
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512236
463
51638
Y45
L
I
R
N
E
F
R
Y
F
Q
K
M
T
T
T
Chicken
Gallus gallus
P00378
189
21631
Y33
P
L
R
N
E
Y
K
Y
F
Q
R
M
T
S
T
Frog
Xenopus laevis
NP_001088506
189
21877
H36
L
L
R
N
E
F
K
H
F
Q
R
L
T
M
T
Zebra Danio
Brachydanio rerio
NP_571850
190
21680
H36
R
L
S
N
E
L
K
H
F
Q
K
M
T
M
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P17719
182
20756
Y32
R
I
K
S
E
L
K
Y
F
S
R
T
T
K
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q93341
189
21583
Y32
R
I
K
K
D
M
Q
Y
F
A
S
V
T
K
N
Sea Urchin
Strong. purpuratus
XP_780421
189
21372
Y37
R
L
R
Q
E
M
A
Y
F
E
R
L
T
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07807
211
24242
Y37
R
L
P
S
E
M
K
Y
F
R
Q
V
T
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.8
87.9
N.A.
89.8
89.8
N.A.
29.8
73.5
62.9
59.4
N.A.
44.3
N.A.
35.4
54.5
Protein Similarity:
100
100
98.9
93.7
N.A.
96.2
96.2
N.A.
34.5
86.2
80.9
74.2
N.A.
64.7
N.A.
57.6
71.4
P-Site Identity:
100
100
100
80
N.A.
93.3
86.6
N.A.
80
80
66.6
53.3
N.A.
33.3
N.A.
20
53.3
P-Site Similarity:
100
100
100
86.6
N.A.
100
93.3
N.A.
93.3
100
86.6
73.3
N.A.
60
N.A.
53.3
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
93
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
58
0
0
100
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% H
% Ile:
0
22
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
15
8
0
0
58
0
0
0
15
0
0
22
0
% K
% Leu:
22
79
0
0
0
15
0
0
0
0
0
15
0
0
8
% L
% Met:
0
0
0
0
0
22
0
0
0
0
0
65
0
15
0
% M
% Asn:
0
0
0
72
0
0
0
0
0
0
0
0
0
0
15
% N
% Pro:
43
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
8
0
0
72
8
0
0
0
0
% Q
% Arg:
36
0
72
0
0
0
29
0
0
8
72
0
0
0
8
% R
% Ser:
0
0
8
15
0
0
0
0
0
8
8
0
0
15
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
8
100
50
72
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
79
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _