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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAH All Species: 36.67
Human Site: T117 Identified Species: 62.05
UniProt: P00439 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00439 NP_000268.1 452 51862 T117 S R D K K K D T V P W F P R T
Chimpanzee Pan troglodytes XP_001156860 452 51858 T117 S R D K K K D T V P W F P R T
Rhesus Macaque Macaca mulatta Q2HZ26 490 56076 D150 T E E E E L E D V P W F P R K
Dog Lupus familis XP_532671 494 56287 Y131 S R L K K D E Y E F F T Y L D
Cat Felis silvestris
Mouse Mus musculus P16331 453 51910 T117 S R D K E K N T V P W F P R T
Rat Rattus norvegicus P04176 453 51803 T117 S R D K E K N T V P W F P R T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507458 568 65241 T233 S R D K K K D T V P W F P R T
Chicken Gallus gallus P70080 445 51121 K112 N I P W Y P K K I S D L D K C
Frog Xenopus laevis Q92142 481 55388 S141 V Q E D D M E S V P W F P K K
Zebra Danio Brachydanio rerio NP_956845 449 51336 T115 S R N K Q K D T V P W F P N D
Tiger Blowfish Takifugu rubipres NP_001027850 454 52112 T119 S R N K E K D T V P W F P N D
Fruit Fly Dros. melanogaster P17276 452 51642 A116 D Y K D N A T A V P W F P R R
Honey Bee Apis mellifera XP_623300 463 53197 T127 N H N D N M G T V P W F P R R
Nematode Worm Caenorhab. elegans P90925 457 52111 S117 K N K Q N K D S V P W F P Q K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 50.6 84.8 N.A. 91.8 92 N.A. 71.4 54.4 52.1 73.8 69.3 61.2 58.5 55.3 N.A.
Protein Similarity: 100 100 66.3 87.2 N.A. 95.8 96.2 N.A. 75.6 69.4 68.4 83.6 81.5 75.8 73.4 71.7 N.A.
P-Site Identity: 100 100 40 26.6 N.A. 86.6 86.6 N.A. 100 0 33.3 73.3 73.3 40 46.6 46.6 N.A.
P-Site Similarity: 100 100 73.3 40 N.A. 100 100 N.A. 100 20 66.6 86.6 86.6 40 60 66.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 8 0 36 22 8 8 43 8 0 0 8 0 8 0 22 % D
% Glu: 0 8 15 8 29 0 22 0 8 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 8 86 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 8 0 15 58 29 58 8 8 0 0 0 0 0 15 22 % K
% Leu: 0 0 8 0 0 8 0 0 0 0 0 8 0 8 0 % L
% Met: 0 0 0 0 0 15 0 0 0 0 0 0 0 0 0 % M
% Asn: 15 8 22 0 22 0 15 0 0 0 0 0 0 15 0 % N
% Pro: 0 0 8 0 0 8 0 0 0 86 0 0 86 0 0 % P
% Gln: 0 8 0 8 8 0 0 0 0 0 0 0 0 8 0 % Q
% Arg: 0 58 0 0 0 0 0 0 0 0 0 0 0 58 15 % R
% Ser: 58 0 0 0 0 0 0 15 0 8 0 0 0 0 0 % S
% Thr: 8 0 0 0 0 0 8 58 0 0 0 8 0 0 36 % T
% Val: 8 0 0 0 0 0 0 0 86 0 0 0 0 0 0 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 86 0 0 0 0 % W
% Tyr: 0 8 0 0 8 0 0 8 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _