Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GOT2 All Species: 55.76
Human Site: Y401 Identified Species: 81.78
UniProt: P00505 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00505 NP_002071.2 430 47476 Y401 L I K E F S I Y M T K D G R I
Chimpanzee Pan troglodytes A5A6K8 413 46215 Y381 L V N E K H I Y L L P S G R I
Rhesus Macaque Macaca mulatta XP_001103601 430 47421 Y401 L T K E F S I Y M T K D G R I
Dog Lupus familis XP_535278 570 61965 Y541 L T K E F S I Y M T K D G R I
Cat Felis silvestris
Mouse Mus musculus P05202 430 47393 Y401 L T K E F S V Y M T K D G R I
Rat Rattus norvegicus P00507 430 47296 Y401 L T K E F S V Y M T K D G R I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507219 458 51187 Y429 L S K E F S I Y M T K D G R I
Chicken Gallus gallus P00508 423 47223 Y394 L T K E F S I Y M T K D G R I
Frog Xenopus laevis NP_001080255 427 47598 Y398 L I K E F S I Y M T K D G R I
Zebra Danio Brachydanio rerio NP_998544 428 47568 Y399 L I N E F S I Y M T K D G R I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_722744 424 47167 Y395 L I K D H S V Y L T N D G R V
Honey Bee Apis mellifera XP_396131 429 48031 Y400 L I R D Y S I Y L T K D G R I
Nematode Worm Caenorhab. elegans Q22067 408 45475 I380 F L L R D G R I N I C G L N T
Sea Urchin Strong. purpuratus XP_001176520 423 46873 Y394 L T K D F S I Y L T K D G R I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P46643 430 47739 Y399 L T S E Y H I Y M T R N G R I
Baker's Yeast Sacchar. cerevisiae P23542 418 46039 Y381 L E E T H A V Y L V A S G R A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 46.9 98.8 71 N.A. 94.8 94.8 N.A. 82.9 83.7 81.8 79.5 N.A. 61.4 62.5 41.8 62.5
Protein Similarity: 100 66.2 99 73.5 N.A. 98.3 98.1 N.A. 87.7 91.8 91.6 88.5 N.A. 77.9 78.5 59.5 77.4
P-Site Identity: 100 46.6 93.3 93.3 N.A. 86.6 86.6 N.A. 93.3 93.3 100 93.3 N.A. 60 73.3 0 80
P-Site Similarity: 100 60 93.3 93.3 N.A. 93.3 93.3 N.A. 93.3 93.3 100 93.3 N.A. 86.6 100 6.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. 54.4 43.7 N.A.
Protein Similarity: N.A. N.A. N.A. 70.7 61.1 N.A.
P-Site Identity: N.A. N.A. N.A. 60 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 0 0 0 0 7 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 0 0 0 19 7 0 0 0 0 0 0 75 0 0 0 % D
% Glu: 0 7 7 69 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 7 0 0 0 63 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 7 0 0 0 0 0 7 94 0 0 % G
% His: 0 0 0 0 13 13 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 32 0 0 0 0 69 7 0 7 0 0 0 0 82 % I
% Lys: 0 0 63 0 7 0 0 0 0 0 69 0 0 0 0 % K
% Leu: 94 7 7 0 0 0 0 0 32 7 0 0 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 % M
% Asn: 0 0 13 0 0 0 0 0 7 0 7 7 0 7 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 7 7 0 0 7 0 0 0 7 0 0 94 0 % R
% Ser: 0 7 7 0 0 75 0 0 0 0 0 13 0 0 0 % S
% Thr: 0 44 0 7 0 0 0 0 0 82 0 0 0 0 7 % T
% Val: 0 7 0 0 0 0 25 0 0 7 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 13 0 0 94 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _