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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GOT2 All Species: 28.48
Human Site: Y75 Identified Species: 41.78
UniProt: P00505 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00505 NP_002071.2 430 47476 Y75 R D D N G K P Y V L P S V R K
Chimpanzee Pan troglodytes A5A6K8 413 46215 E70 N D N S L N H E Y L P I L G L
Rhesus Macaque Macaca mulatta XP_001103601 430 47421 Y75 R D D N G K P Y V L P S V R K
Dog Lupus familis XP_535278 570 61965 Y215 R D D N G K P Y V L P S V R K
Cat Felis silvestris
Mouse Mus musculus P05202 430 47393 Y75 R D D N G K P Y V L P S V R K
Rat Rattus norvegicus P00507 430 47296 Y75 R D D N G K P Y V L P S V R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507219 458 51187 Y103 R D D S G K P Y V L P S V R K
Chicken Gallus gallus P00508 423 47223 L70 D N G K S Y V L N C V R K A E
Frog Xenopus laevis NP_001080255 427 47598 Y72 R D D N G K P Y V L S S V R K
Zebra Danio Brachydanio rerio NP_998544 428 47568 F73 R D D Q G K P F V L S S V R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_722744 424 47167 V70 D D N T Q P F V L P S V R E A
Honey Bee Apis mellifera XP_396131 429 48031 F74 R D D N G K P F V L P S V R K
Nematode Worm Caenorhab. elegans Q22067 408 45475 L72 N H E Y L P V L G H E G F R K
Sea Urchin Strong. purpuratus XP_001176520 423 46873 F76 R D D E G K P F V L Q S V K Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P46643 430 47739 V75 R D D N G K P V V L E C V R E
Baker's Yeast Sacchar. cerevisiae P23542 418 46039 T74 N H E Y L G I T G L P S L T S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 46.9 98.8 71 N.A. 94.8 94.8 N.A. 82.9 83.7 81.8 79.5 N.A. 61.4 62.5 41.8 62.5
Protein Similarity: 100 66.2 99 73.5 N.A. 98.3 98.1 N.A. 87.7 91.8 91.6 88.5 N.A. 77.9 78.5 59.5 77.4
P-Site Identity: 100 20 100 100 N.A. 100 100 N.A. 93.3 0 93.3 80 N.A. 6.6 93.3 13.3 66.6
P-Site Similarity: 100 40 100 100 N.A. 100 100 N.A. 100 13.3 93.3 86.6 N.A. 20 100 20 86.6
Percent
Protein Identity: N.A. N.A. N.A. 54.4 43.7 N.A.
Protein Similarity: N.A. N.A. N.A. 70.7 61.1 N.A.
P-Site Identity: N.A. N.A. N.A. 73.3 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 7 0 0 0 % C
% Asp: 13 82 69 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 13 7 0 0 0 7 0 0 13 0 0 7 13 % E
% Phe: 0 0 0 0 0 0 7 19 0 0 0 0 7 0 0 % F
% Gly: 0 0 7 0 69 7 0 0 13 0 0 7 0 7 0 % G
% His: 0 13 0 0 0 0 7 0 0 7 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 7 0 0 0 0 7 0 0 0 % I
% Lys: 0 0 0 7 0 69 0 0 0 0 0 0 7 7 63 % K
% Leu: 0 0 0 0 19 0 0 13 7 82 0 0 13 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 19 7 13 50 0 7 0 0 7 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 13 69 0 0 7 57 0 0 0 0 % P
% Gln: 0 0 0 7 7 0 0 0 0 0 7 0 0 0 7 % Q
% Arg: 69 0 0 0 0 0 0 0 0 0 0 7 7 69 0 % R
% Ser: 0 0 0 13 7 0 0 0 0 0 19 69 0 0 7 % S
% Thr: 0 0 0 7 0 0 0 7 0 0 0 0 0 7 0 % T
% Val: 0 0 0 0 0 0 13 13 69 0 7 7 69 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 13 0 7 0 44 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _