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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MOS All Species: 26.36
Human Site: S99 Identified Species: 48.33
UniProt: P00540 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00540 NP_005363.1 346 37820 S99 C T K N R L A S R R S F W A E
Chimpanzee Pan troglodytes XP_528144 346 37828 S99 C T K N R L A S R R S F W A E
Rhesus Macaque Macaca mulatta XP_001087400 305 33010 G70 L Q R L G A G G F G S V Y K A
Dog Lupus familis XP_544088 372 41133 S126 C T K N R L A S Q R S F W A E
Cat Felis silvestris
Mouse Mus musculus P00536 390 42872 S149 C T K D L R A S Q R S F W A E
Rat Rattus norvegicus P00539 339 37603 S100 C T R T L R A S Q R N F W A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P10741 349 38245 S103 S S K N R L A S R Q S F W A E
Frog Xenopus laevis P12965 359 39143 S102 S T K N S L A S R Q S F W A E
Zebra Danio Brachydanio rerio NP_991143 329 36509 N94 K K V K C V K N K L A S R Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9U1Y5 476 53320 P146 D L I S I G I P A L I I F V Y
Sea Urchin Strong. purpuratus XP_789415 418 47752 A116 R I I T H Q H A S R T T Y H C
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001130627 368 40934 S95 E V A I K M V S Q P E E D A A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2MHE4 390 44263 G103 A H S R I Y R G I Y K Q R A V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 85.5 78.4 N.A. 65.3 71 N.A. N.A. 62.1 53.7 46.5 N.A. N.A. N.A. 20.1 26.3
Protein Similarity: 100 99.4 86.4 83.5 N.A. 71.7 78.9 N.A. N.A. 72.7 66.5 62.1 N.A. N.A. N.A. 36.1 40.6
P-Site Identity: 100 100 6.6 93.3 N.A. 73.3 60 N.A. N.A. 80 80 0 N.A. N.A. N.A. 0 6.6
P-Site Similarity: 100 100 20 100 N.A. 86.6 80 N.A. N.A. 93.3 86.6 26.6 N.A. N.A. N.A. 13.3 26.6
Percent
Protein Identity: N.A. 29.6 N.A. 22.8 N.A. N.A.
Protein Similarity: N.A. 43.2 N.A. 42 N.A. N.A.
P-Site Identity: N.A. 13.3 N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. 33.3 N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 0 8 54 8 8 0 8 0 0 70 16 % A
% Cys: 39 0 0 0 8 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 8 0 0 8 0 0 0 0 0 0 0 0 8 0 0 % D
% Glu: 8 0 0 0 0 0 0 0 0 0 8 8 0 0 54 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 54 8 0 0 % F
% Gly: 0 0 0 0 8 8 8 16 0 8 0 0 0 0 0 % G
% His: 0 8 0 0 8 0 8 0 0 0 0 0 0 8 0 % H
% Ile: 0 8 16 8 16 0 8 0 8 0 8 8 0 0 0 % I
% Lys: 8 8 47 8 8 0 8 0 8 0 8 0 0 8 0 % K
% Leu: 8 8 0 8 16 39 0 0 0 16 0 0 0 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 39 0 0 0 8 0 0 8 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 8 0 0 31 16 0 8 0 8 0 % Q
% Arg: 8 0 16 8 31 16 8 0 31 47 0 0 16 0 0 % R
% Ser: 16 8 8 8 8 0 0 62 8 0 54 8 0 0 8 % S
% Thr: 0 47 0 16 0 0 0 0 0 0 8 8 0 0 0 % T
% Val: 0 8 8 0 0 8 8 0 0 0 0 8 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 54 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 8 0 0 16 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _