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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: F2 All Species: 15.15
Human Site: S199 Identified Species: 27.78
UniProt: P00734 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00734 NP_000497.1 622 70037 S199 T V A M T P R S E G S S V N L
Chimpanzee Pan troglodytes Q95ND7 461 51746 E66 N L E R E C M E E K C S F E E
Rhesus Macaque Macaca mulatta NP_001098055 627 70600 S207 T V A M T P R S S V N L S L P
Dog Lupus familis XP_855946 493 54567 Q98 E S S P C Q N Q G Q C K D G L
Cat Felis silvestris
Mouse Mus musculus P19221 618 70250 S201 T V V M T P R S G G S K D N L
Rat Rattus norvegicus P18292 617 70393 S201 T V K M T P R S R G S K E N L
Wallaby Macropus eugenll O18783 806 90963 R194 H C S G E N Y R G T I S K T E
Platypus Ornith. anatinus XP_001511876 701 76014 T286 E G R L Y R G T Q A T T L S G
Chicken Gallus gallus P25155 475 53123 F80 D N E K T E E F W N I Y V D G
Frog Xenopus laevis NP_001086517 607 69214 T189 T V C G T N K T T V E P L L V
Zebra Danio Brachydanio rerio NP_998555 524 59542 K129 A G K V S V T K S G K A C Q Y
Tiger Blowfish Takifugu rubipres NP_001027864 612 69604 P197 C G E A F V P P T P T P K H F
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783851 948 105521 T299 V L G K R D F T R P N A L F A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28.4 92.6 32.9 N.A. 81.1 79.9 23.3 44.3 31.1 58.6 50.3 52.8 N.A. N.A. N.A. 24.4
Protein Similarity: 100 43.8 95 45.3 N.A. 88.7 88 37.1 54.2 46.7 74.4 64.4 70.7 N.A. N.A. N.A. 37.2
P-Site Identity: 100 13.3 53.3 6.6 N.A. 73.3 73.3 6.6 0 13.3 20 6.6 0 N.A. N.A. N.A. 0
P-Site Similarity: 100 20 60 13.3 N.A. 73.3 73.3 13.3 46.6 20 46.6 26.6 13.3 N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 16 8 0 0 0 0 0 8 0 16 0 0 8 % A
% Cys: 8 8 8 0 8 8 0 0 0 0 16 0 8 0 0 % C
% Asp: 8 0 0 0 0 8 0 0 0 0 0 0 16 8 0 % D
% Glu: 16 0 24 0 16 8 8 8 16 0 8 0 8 8 16 % E
% Phe: 0 0 0 0 8 0 8 8 0 0 0 0 8 8 8 % F
% Gly: 0 24 8 16 0 0 8 0 24 31 0 0 0 8 16 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 16 0 0 0 0 % I
% Lys: 0 0 16 16 0 0 8 8 0 8 8 24 16 0 0 % K
% Leu: 0 16 0 8 0 0 0 0 0 0 0 8 24 16 31 % L
% Met: 0 0 0 31 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 0 0 16 8 0 0 8 16 0 0 24 0 % N
% Pro: 0 0 0 8 0 31 8 8 0 16 0 16 0 0 8 % P
% Gln: 0 0 0 0 0 8 0 8 8 8 0 0 0 8 0 % Q
% Arg: 0 0 8 8 8 8 31 8 16 0 0 0 0 0 0 % R
% Ser: 0 8 16 0 8 0 0 31 16 0 24 24 8 8 0 % S
% Thr: 39 0 0 0 47 0 8 24 16 8 16 8 0 8 0 % T
% Val: 8 39 8 8 0 16 0 0 0 16 0 0 16 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 8 0 0 0 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _