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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: F2 All Species: 20.91
Human Site: T351 Identified Species: 38.33
UniProt: P00734 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00734 NP_000497.1 622 70037 T351 K K S L E D K T E R E L L E S
Chimpanzee Pan troglodytes Q95ND7 461 51746 L211 S T E A E T I L D N I T Q S T
Rhesus Macaque Macaca mulatta NP_001098055 627 70600 T356 K K S L E D K T E G E L L E S
Dog Lupus familis XP_855946 493 54567 G243 G L V R I V G G Q D C R D G E
Cat Felis silvestris
Mouse Mus musculus P19221 618 70250 T348 K K S L K D T T E K E L L D S
Rat Rattus norvegicus P18292 617 70393 T347 K K S L T D K T E K E L L D S
Wallaby Macropus eugenll O18783 806 90963 P411 K K T P D N F P N A D L I R N
Platypus Ornith. anatinus XP_001511876 701 76014 R432 Q V A A R G R R G S N D R G G
Chicken Gallus gallus P25155 475 53123 P225 T T E S P T P P P R N G S S I
Frog Xenopus laevis NP_001086517 607 69214 S336 Q K S V E D K S E K E L L E S
Zebra Danio Brachydanio rerio NP_998555 524 59542 A274 D E A E V A S A P W Q V M L Y
Tiger Blowfish Takifugu rubipres NP_001027864 612 69604 S345 Q K N K K D A S E D E L L Q S
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783851 948 105521 A694 G T V T S P E A T M F T T P G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28.4 92.6 32.9 N.A. 81.1 79.9 23.3 44.3 31.1 58.6 50.3 52.8 N.A. N.A. N.A. 24.4
Protein Similarity: 100 43.8 95 45.3 N.A. 88.7 88 37.1 54.2 46.7 74.4 64.4 70.7 N.A. N.A. N.A. 37.2
P-Site Identity: 100 6.6 93.3 0 N.A. 73.3 80 20 0 6.6 73.3 0 46.6 N.A. N.A. N.A. 0
P-Site Similarity: 100 20 93.3 6.6 N.A. 93.3 93.3 60 20 6.6 100 33.3 80 N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 16 0 8 8 16 0 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 8 0 0 0 8 47 0 0 8 16 8 8 8 16 0 % D
% Glu: 0 8 16 8 31 0 8 0 47 0 47 0 0 24 8 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 8 0 0 0 0 % F
% Gly: 16 0 0 0 0 8 8 8 8 8 0 8 0 16 16 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 8 0 0 0 8 0 8 0 8 % I
% Lys: 39 54 0 8 16 0 31 0 0 24 0 0 0 0 0 % K
% Leu: 0 8 0 31 0 0 0 8 0 0 0 54 47 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % M
% Asn: 0 0 8 0 0 8 0 0 8 8 16 0 0 0 8 % N
% Pro: 0 0 0 8 8 8 8 16 16 0 0 0 0 8 0 % P
% Gln: 24 0 0 0 0 0 0 0 8 0 8 0 8 8 0 % Q
% Arg: 0 0 0 8 8 0 8 8 0 16 0 8 8 8 0 % R
% Ser: 8 0 39 8 8 0 8 16 0 8 0 0 8 16 47 % S
% Thr: 8 24 8 8 8 16 8 31 8 0 0 16 8 0 8 % T
% Val: 0 8 16 8 8 8 0 0 0 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _