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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: F2 All Species: 27.88
Human Site: Y603 Identified Species: 51.11
UniProt: P00734 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00734 NP_000497.1 622 70037 Y603 R D G K Y G F Y T H V F R L K
Chimpanzee Pan troglodytes Q95ND7 461 51746 W453 K V S R Y V N W I K E K T K L
Rhesus Macaque Macaca mulatta NP_001098055 627 70600 Y608 R D G K Y G F Y T H V F R L K
Dog Lupus familis XP_855946 493 54567 P485 M K A R G A A P A L A G G P H
Cat Felis silvestris
Mouse Mus musculus P19221 618 70250 Y600 R K G K Y G F Y T H V F R L K
Rat Rattus norvegicus P18292 617 70393 Y599 R N G K Y G F Y T H V F R L K
Wallaby Macropus eugenll O18783 806 90963 Y789 R P N K P G V Y V R V S R Y I
Platypus Ornith. anatinus XP_001511876 701 76014 Y682 R D G K Y G F Y T H V F R L K
Chicken Gallus gallus P25155 475 53123 W467 K L S R F L R W V R T V M R Q
Frog Xenopus laevis NP_001086517 607 69214 Y587 R D G K Y G F Y V H L H R L R
Zebra Danio Brachydanio rerio NP_998555 524 59542 E516 R W M K K V I E K T D S G D D
Tiger Blowfish Takifugu rubipres NP_001027864 612 69604 Y596 R D G K Y G F Y T H V F R M T
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783851 948 105521 H939 Y T K I L R L H S W I D R N I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28.4 92.6 32.9 N.A. 81.1 79.9 23.3 44.3 31.1 58.6 50.3 52.8 N.A. N.A. N.A. 24.4
Protein Similarity: 100 43.8 95 45.3 N.A. 88.7 88 37.1 54.2 46.7 74.4 64.4 70.7 N.A. N.A. N.A. 37.2
P-Site Identity: 100 6.6 100 0 N.A. 93.3 93.3 40 100 0 73.3 13.3 86.6 N.A. N.A. N.A. 6.6
P-Site Similarity: 100 26.6 100 6.6 N.A. 93.3 100 40 100 33.3 86.6 13.3 93.3 N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 8 8 0 8 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 39 0 0 0 0 0 0 0 0 8 8 0 8 8 % D
% Glu: 0 0 0 0 0 0 0 8 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 8 0 54 0 0 0 0 47 0 0 0 % F
% Gly: 0 0 54 0 8 62 0 0 0 0 0 8 16 0 0 % G
% His: 0 0 0 0 0 0 0 8 0 54 0 8 0 0 8 % H
% Ile: 0 0 0 8 0 0 8 0 8 0 8 0 0 0 16 % I
% Lys: 16 16 8 70 8 0 0 0 8 8 0 8 0 8 39 % K
% Leu: 0 8 0 0 8 8 8 0 0 8 8 0 0 47 8 % L
% Met: 8 0 8 0 0 0 0 0 0 0 0 0 8 8 0 % M
% Asn: 0 8 8 0 0 0 8 0 0 0 0 0 0 8 0 % N
% Pro: 0 8 0 0 8 0 0 8 0 0 0 0 0 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Q
% Arg: 70 0 0 24 0 8 8 0 0 16 0 0 70 8 8 % R
% Ser: 0 0 16 0 0 0 0 0 8 0 0 16 0 0 0 % S
% Thr: 0 8 0 0 0 0 0 0 47 8 8 0 8 0 8 % T
% Val: 0 8 0 0 0 16 8 0 24 0 54 8 0 0 0 % V
% Trp: 0 8 0 0 0 0 0 16 0 8 0 0 0 0 0 % W
% Tyr: 8 0 0 0 62 0 0 62 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _