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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: C1R All Species: 27.88
Human Site: Y404 Identified Species: 68.15
UniProt: P00736 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00736 NP_001724.3 705 80119 Y404 T Y K A R I Q Y Y C H E P Y Y
Chimpanzee Pan troglodytes Q5R1W3 705 80186 Y404 T Y K A R I Q Y Y C H E T Y Y
Rhesus Macaque Macaca mulatta XP_001118325 431 49482 A201 S S E L Y T E A S G Y I S S L
Dog Lupus familis XP_534901 705 80112 Y404 T Y Q A R I Q Y Y C Q E P Y Y
Cat Felis silvestris
Mouse Mus musculus Q8CG16 707 80055 Y403 T Y E A S I Q Y H C H E P Y Y
Rat Rattus norvegicus Q9JJS8 685 75648 Y394 T Y K A V I Q Y S C E E T F Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510548 728 80898 Y391 T Y E A E I Q Y S C K I P F Y
Chicken Gallus gallus XP_416518 712 80488 Y405 T Y Q S V I T Y Q C N E P Y Y
Frog Xenopus laevis NP_001090130 708 80164 Y398 E Y E S V I Q Y H C N E P Y Y
Zebra Danio Brachydanio rerio NP_001116330 684 76146 Y409 Y T C A H D G Y W R D A L G G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 59 84.5 N.A. 81.1 41.7 N.A. 40.1 60.6 50.5 40 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.5 60.2 92.4 N.A. 88.9 57.1 N.A. 57.1 76.8 69 57.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 0 86.6 N.A. 80 66.6 N.A. 60 60 60 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 26.6 93.3 N.A. 93.3 73.3 N.A. 73.3 80 86.6 20 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 70 0 0 0 10 0 0 0 10 0 0 0 % A
% Cys: 0 0 10 0 0 0 0 0 0 80 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 0 10 0 0 0 0 % D
% Glu: 10 0 40 0 10 0 10 0 0 0 10 70 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 10 0 0 0 10 10 % G
% His: 0 0 0 0 10 0 0 0 20 0 30 0 0 0 0 % H
% Ile: 0 0 0 0 0 80 0 0 0 0 0 20 0 0 0 % I
% Lys: 0 0 30 0 0 0 0 0 0 0 10 0 0 0 0 % K
% Leu: 0 0 0 10 0 0 0 0 0 0 0 0 10 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 20 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 60 0 0 % P
% Gln: 0 0 20 0 0 0 70 0 10 0 10 0 0 0 0 % Q
% Arg: 0 0 0 0 30 0 0 0 0 10 0 0 0 0 0 % R
% Ser: 10 10 0 20 10 0 0 0 30 0 0 0 10 10 0 % S
% Thr: 70 10 0 0 0 10 10 0 0 0 0 0 20 0 0 % T
% Val: 0 0 0 0 30 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 10 80 0 0 10 0 0 90 30 0 10 0 0 60 80 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _