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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADA All Species: 13.64
Human Site: S333 Identified Species: 27.27
UniProt: P00813 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00813 NP_000013.2 363 40764 S333 N I N A A K S S F L P E D E K
Chimpanzee Pan troglodytes XP_001144517 363 40678 S333 N I N A A K S S F L P E D E K
Rhesus Macaque Macaca mulatta XP_001109908 572 62188 S542 N I N A A K S S F L P E D E K
Dog Lupus familis XP_534428 362 41003 S332 N I N A A K S S F L P E D E K
Cat Felis silvestris
Mouse Mus musculus P03958 352 39973 K323 G F T E E E F K R L N I N A A
Rat Rattus norvegicus Q920P6 352 39881 K323 G F T E E E F K R L N I N A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508594 308 34510 D279 S Y L T G A C D P D F S K H P
Chicken Gallus gallus Q5ZKP6 357 40660 I326 E D F K R V N I N A A Q S S F
Frog Xenopus laevis Q6GP70 358 40658 A329 K R V N I N A A K S S F L P D
Zebra Danio Brachydanio rerio Q6DG22 359 40825 A330 K R L N I N A A K S C F L P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_501087 391 43657 I351 L T L V H K Q I G L D V H Q L
Sea Urchin Strong. purpuratus XP_785367 391 43729 N362 F T D S Q M K N M T L N A A Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 61.3 85.6 N.A. 80.9 83.1 N.A. 58.9 65.5 69.1 64.1 N.A. N.A. N.A. 31.4 35.8
Protein Similarity: 100 99.4 62.7 91.4 N.A. 90.6 91.4 N.A. 68.3 79 81.8 78.5 N.A. N.A. N.A. 50.3 54.4
P-Site Identity: 100 100 100 100 N.A. 6.6 6.6 N.A. 0 0 0 0 N.A. N.A. N.A. 13.3 0
P-Site Similarity: 100 100 100 100 N.A. 20 20 N.A. 6.6 13.3 13.3 20 N.A. N.A. N.A. 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 34 34 9 17 17 0 9 9 0 9 25 17 % A
% Cys: 0 0 0 0 0 0 9 0 0 0 9 0 0 0 0 % C
% Asp: 0 9 9 0 0 0 0 9 0 9 9 0 34 0 9 % D
% Glu: 9 0 0 17 17 17 0 0 0 0 0 34 0 34 9 % E
% Phe: 9 17 9 0 0 0 17 0 34 0 9 17 0 0 9 % F
% Gly: 17 0 0 0 9 0 0 0 9 0 0 0 0 0 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 9 9 0 % H
% Ile: 0 34 0 0 17 0 0 17 0 0 0 17 0 0 0 % I
% Lys: 17 0 0 9 0 42 9 17 17 0 0 0 9 0 34 % K
% Leu: 9 0 25 0 0 0 0 0 0 59 9 0 17 0 9 % L
% Met: 0 0 0 0 0 9 0 0 9 0 0 0 0 0 0 % M
% Asn: 34 0 34 17 0 17 9 9 9 0 17 9 17 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 9 0 34 0 0 17 9 % P
% Gln: 0 0 0 0 9 0 9 0 0 0 0 9 0 9 9 % Q
% Arg: 0 17 0 0 9 0 0 0 17 0 0 0 0 0 0 % R
% Ser: 9 0 0 9 0 0 34 34 0 17 9 9 9 9 0 % S
% Thr: 0 17 17 9 0 0 0 0 0 9 0 0 0 0 0 % T
% Val: 0 0 9 9 0 9 0 0 0 0 0 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _