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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KRAS
All Species:
8.79
Human Site:
T177
Identified Species:
19.33
UniProt:
P01116
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P01116
NP_004976.2
189
21656
T177
K
I
S
K
E
E
K
T
P
G
C
V
K
I
K
Chimpanzee
Pan troglodytes
XP_521702
189
21289
S177
K
L
N
P
P
D
E
S
G
P
G
C
M
S
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_540523
226
24555
G214
K
L
S
P
P
D
E
G
G
P
G
C
M
S
C
Cat
Felis silvestris
Mouse
Mus musculus
P32883
189
21637
T177
K
I
S
K
E
E
K
T
P
G
C
V
K
I
K
Rat
Rattus norvegicus
Q04970
189
21225
G177
K
L
N
S
S
E
D
G
T
Q
G
C
M
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P08642
189
21347
S177
K
L
N
P
P
D
E
S
G
P
G
C
M
N
C
Frog
Xenopus laevis
Q91806
189
21364
N177
K
L
D
S
S
E
D
N
N
Q
G
C
I
R
I
Zebra Danio
Brachydanio rerio
P79737
188
21321
R176
K
L
N
S
R
E
D
R
K
Q
G
C
L
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08646
189
21575
M177
K
G
R
R
G
R
K
M
N
K
P
N
R
R
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P22981
184
20964
K177
H
D
N
N
K
P
Q
K
K
K
K
C
Q
I
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P22126
213
24008
T183
L
G
E
K
V
G
G
T
S
F
A
N
N
N
G
Conservation
Percent
Protein Identity:
100
86.2
N.A.
72.5
N.A.
98.9
87.8
N.A.
N.A.
88.3
88.8
85.7
N.A.
76.7
N.A.
75.6
N.A.
Protein Similarity:
100
93.6
N.A.
79.1
N.A.
100
94.7
N.A.
N.A.
94.7
94.1
93.1
N.A.
86.2
N.A.
85.7
N.A.
P-Site Identity:
100
6.6
N.A.
13.3
N.A.
100
13.3
N.A.
N.A.
6.6
13.3
13.3
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
40
N.A.
33.3
N.A.
100
26.6
N.A.
N.A.
40
20
26.6
N.A.
26.6
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
59.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
69.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
19
64
0
0
28
% C
% Asp:
0
10
10
0
0
28
28
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
10
0
19
46
28
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
10
% F
% Gly:
0
19
0
0
10
10
10
19
28
19
55
0
0
19
10
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
19
0
0
0
0
0
0
0
0
0
0
10
28
10
% I
% Lys:
82
0
0
28
10
0
28
10
19
19
10
0
19
0
19
% K
% Leu:
10
55
0
0
0
0
0
0
0
0
0
0
10
0
10
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
37
0
10
% M
% Asn:
0
0
46
10
0
0
0
10
19
0
0
19
10
19
0
% N
% Pro:
0
0
0
28
28
10
0
0
19
28
10
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
28
0
0
10
0
0
% Q
% Arg:
0
0
10
10
10
10
0
10
0
0
0
0
10
19
0
% R
% Ser:
0
0
28
28
19
0
0
19
10
0
0
0
0
19
0
% S
% Thr:
0
0
0
0
0
0
0
28
10
0
0
0
0
0
0
% T
% Val:
0
0
0
0
10
0
0
0
0
0
0
19
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _