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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KRAS
All Species:
16.36
Human Site:
Y166
Identified Species:
36
UniProt:
P01116
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P01116
NP_004976.2
189
21656
Y166
L
V
R
E
I
R
Q
Y
R
L
K
K
I
S
K
Chimpanzee
Pan troglodytes
XP_521702
189
21289
H166
L
V
R
E
I
R
Q
H
K
L
R
K
L
N
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_540523
226
24555
H203
L
V
R
E
I
R
Q
H
K
V
R
K
L
S
P
Cat
Felis silvestris
Mouse
Mus musculus
P32883
189
21637
Y166
L
V
R
E
I
R
Q
Y
R
L
K
K
I
S
K
Rat
Rattus norvegicus
Q04970
189
21225
Y166
L
V
R
E
I
R
Q
Y
R
M
K
K
L
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P08642
189
21347
H166
L
V
R
E
I
R
Q
H
K
L
R
K
L
N
P
Frog
Xenopus laevis
Q91806
189
21364
Y166
L
V
R
E
I
H
Q
Y
R
M
K
K
L
D
S
Zebra Danio
Brachydanio rerio
P79737
188
21321
Y165
L
V
R
E
I
R
H
Y
R
M
K
K
L
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08646
189
21575
D166
L
V
R
E
I
R
K
D
K
D
N
K
G
R
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P22981
184
20964
H166
L
V
R
E
I
R
K
H
R
E
R
H
D
N
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P22126
213
24008
E172
L
V
R
E
I
R
K
E
D
K
K
L
G
E
K
Conservation
Percent
Protein Identity:
100
86.2
N.A.
72.5
N.A.
98.9
87.8
N.A.
N.A.
88.3
88.8
85.7
N.A.
76.7
N.A.
75.6
N.A.
Protein Similarity:
100
93.6
N.A.
79.1
N.A.
100
94.7
N.A.
N.A.
94.7
94.1
93.1
N.A.
86.2
N.A.
85.7
N.A.
P-Site Identity:
100
60
N.A.
60
N.A.
100
73.3
N.A.
N.A.
60
66.6
66.6
N.A.
46.6
N.A.
46.6
N.A.
P-Site Similarity:
100
93.3
N.A.
93.3
N.A.
100
93.3
N.A.
N.A.
93.3
80
86.6
N.A.
66.6
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
59.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
69.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
10
10
0
0
10
10
0
% D
% Glu:
0
0
0
100
0
0
0
10
0
10
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% G
% His:
0
0
0
0
0
10
10
37
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
100
0
0
0
0
0
0
0
19
0
0
% I
% Lys:
0
0
0
0
0
0
28
0
37
10
55
82
0
0
28
% K
% Leu:
100
0
0
0
0
0
0
0
0
37
0
10
55
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
28
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
10
0
0
46
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
28
% P
% Gln:
0
0
0
0
0
0
64
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
100
0
0
91
0
0
55
0
37
0
0
10
10
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
28
28
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
100
0
0
0
0
0
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
46
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _